Document Detail


Prevalence and genotypic characteristics of Clostridium difficile in a closed and integrated human and swine population.
MedLine Citation:
PMID:  21724899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recently, an apparent rise in the number of cases attributed to community-acquired Clostridium difficile infection has led researchers to explore additional sources of infection. The finding of C. difficile in food animals and retail meat has raised concern about potential food-borne and occupational exposures. The objective of this study was to compare C. difficile isolated from a closed population of healthy individuals consisting of both humans and swine in order to investigate possible food safety and occupational risks for exposure. Using a multistep enrichment isolation technique, we identified 11.8% of the human wastewater samples and 8.6% of the swine samples that were positive for C. difficile. The prevalences of C. difficile in swine production groups differed significantly (P < 0.05); however, the prevalences in the two human occupational group cohorts did not differ significantly (P = 0.81). The majority of the human and swine isolates were similar based on multiple typing methods. The similarity in C. difficile prevalence in the human group cohorts suggests a low occupational hazard, while a greatly decreased prevalence of C. difficile in later-stage swine production groups suggests a diminished risk for food-borne exposure. The similarity of strains in the two host species suggests the possibility of a common environmental source for healthy individuals in a community setting.
Authors:
Keri N Norman; H Morgan Scott; Roger B Harvey; Bo Norby; Michael E Hume; Kathleen Andrews
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-07-01
Journal Detail:
Title:  Applied and environmental microbiology     Volume:  77     ISSN:  1098-5336     ISO Abbreviation:  Appl. Environ. Microbiol.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-05     Completed Date:  2011-12-15     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  7605801     Medline TA:  Appl Environ Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5755-60     Citation Subset:  IM    
Affiliation:
Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas 77843, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacterial Typing Techniques
Clostridium difficile / classification,  genetics*,  isolation & purification*
Cohort Studies
Electrophoresis, Gel, Pulsed-Field
Feces / microbiology*
Food Safety
Genotype
Humans
Logistic Models
Prevalence
Risk Factors
Seasons
Swine / microbiology*
Water Microbiology
Comments/Corrections

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