Document Detail

Prevalence of elevated hemoglobin A2 measured by the CAPILLARYS system.
MedLine Citation:
PMID:  19095564     Owner:  NLM     Status:  MEDLINE    
Hemoglobin (Hb) A2 electrophoresis has been used for prenatal screening for the beta-thalassemia trait (betaTT). We retrospectively reviewed Hb capillary electrophoresis performed in our laboratory. We found that of the 122 cases showing elevated HbA2 levels, 79 cases were due to hemoglobinopathies, mostly HbS. Review of the RBC indices suggested that 3 of 36 cases with elevation of HbA2 in the HbAA-pregnancy group had betaTT and 29 had normal RBC indices; data were not available for 4 patients. Among 7 cases with elevation of HbA2 in the HbAA-other group, 5 had betaTT and 2 were normal. The number of patients without betaTT but with HbA2 elevation in the pregnant group was significantly higher than that in the nonpregnant group. When a higher HbA2 cutoff (3.5%) was used, only 3 pregnant patients without betaTT had HbA2 elevation, similar to the nonpregnant group. We found that a significant number of pregnant women with mild HbA2 elevation had no evidence of betaTT, compared with the nonpregnant group.
Zhaohai Yang; Carolyn H Chaffin; Pattye L Easley; Beatrice Thigpen; Vishnu V B Reddy
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Publication Detail:
Type:  Journal Article; Validation Studies    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  131     ISSN:  1943-7722     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-19     Completed Date:  2009-01-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  42-8     Citation Subset:  AIM; IM    
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
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MeSH Terms
Electrophoresis, Capillary
Hemoglobin A2 / analysis*
Pregnancy Complications, Hematologic / blood,  epidemiology
Prenatal Diagnosis
Retrospective Studies
beta-Thalassemia / diagnosis*,  genetics
Reg. No./Substance:
9034-53-1/Hemoglobin A2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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