Document Detail


Prevalence and distribution of abdominal aortic calcium by gender and age group in a community-based cohort (from the Framingham Heart Study).
MedLine Citation:
PMID:  22727181     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Abdominal aortic calcium (AAC) is associated with incident cardiovascular disease. However, the age- and gender-related distribution of AAC in a community-dwelling population free of standard cardiovascular disease risk factors has not been described. A total of 3,285 participants (aged 50.2 ± 9.9 years) in the Framingham Heart Study Offspring and Third Generation cohorts underwent abdominal multidetector computed tomography from 1998 to 2005. The presence and amount of AAC was quantified (Agatston score) by an experienced reader using standardized criteria. A healthy referent subsample (n = 1,656, 803 men) free of hypertension, hyperlipidemia, diabetes, obesity, and smoking was identified, and participants were stratified by gender and age (<45, 45 to 54, 55 to 64, 65 to 74, and ≥75 years). The prevalence and burden of AAC increased monotonically and supra-linearly with age in both genders but was greater in men than in women in each age group. For those <45 years old, <16% of the referent subsample participants had any quantifiable AAC. However, for those >65 years old, nearly 90% of the referent participants had >0 AAC. Across the entire study sample, AAC prevalence and burden similarly increased with greater age. Defining the 90th percentile of the referent group AAC as "high," the prevalence of high AAC was 19% for each gender in the overall study sample. The AAC also increased across categories of 10-year coronary heart disease risk, as calculated using the Framingham Risk Score, in the entire study sample. We found AAC to be widely prevalent, with the burden of AAC associated with 10-year coronary risk, in a white, free-living adult cohort.
Authors:
Michael L Chuang; Joseph M Massaro; Yamini S Levitzky; Caroline S Fox; Emily S Manders; Udo Hoffmann; Christopher J O'Donnell
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2012-06-20
Journal Detail:
Title:  The American journal of cardiology     Volume:  110     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-31     Completed Date:  2013-04-12     Revised Date:  2013-09-18    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  891-6     Citation Subset:  AIM; IM    
Copyright Information:
Published by Elsevier Inc.
Affiliation:
National Heart, Lung, and Blood Institute's Framingham Heart Study, Boston University School of Public Health, Boston, MA, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aorta, Abdominal / pathology*,  radiography
Aortic Diseases / epidemiology*,  radiography
Calcinosis / epidemiology*,  radiography
Cohort Studies
Female
Humans
Male
Middle Aged
Multidetector Computed Tomography
Prevalence
Risk Factors
Grant Support
ID/Acronym/Agency:
N01-HC-25195/HC/NHLBI NIH HHS; N01-HC-38038/HC/NHLBI NIH HHS; N01HC25195/HL/NHLBI NIH HHS; Z01 HL006002-01/HL/NHLBI NIH HHS; Z99 HL999999/HL/NHLBI NIH HHS; ZIA HL006002-04/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Comparison of Accuracy of Mitral Valve Regurgitation Volume Determined by Three-Dimensional Transeso...
Next Document:  Effect of Nicotine Replacement Therapy on Cardiovascular Outcomes After Acute Coronary Syndromes.