Document Detail


Prevalence of Coronary Atherosclerosis in Asymptomatic Healthy Subjects: An Intravascular Ultrasound Study of Donor Hearts.
MedLine Citation:
PMID:  23385059     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aim: At present, limited in vivo information is available on the prevalence and severity of coronary atherosclerosis in asymptomatic healthy subjects. The aim of this study was to examine the prevalence, extent and severity of coronary atherosclerosis in healthy individuals.Methods: We performed an intravascular ultrasound (IVUS) examination on 198 heart transplant recipients 4 weeks after transplantation. The donor population consisted of 147 men and 51 women (31.4±11.0 years). The left anterior descending coronary artery was imaged in all patients, and 3 vessel images were obtained for 99 patients.Results: Angiographic appearance was completely normal in 177 of the 198 subjects (89.4%), while atherosclerotic luminal irregularities were observed in the remaining individuals. IVUS revealed that atherosclerotic lesions (defined as intimal thickness ≥0.5 mm at any site) were present in 96 patients (48.5%). The prevalence of coronary atherosclerosis rapidly increased with age (10-19 years, 5.9%; 20-29 years, 31.1%; 30-39 years, 59.0%; 40-49 years, 78.4%). In the diseased subgroup, atherosclerotic lesions were mostly eccentric (92.7%), with maximal intimal thickness of 0.99±0.42 mm (area stenosis, 32.2±11.7%). All coronary arteries were predominantly located in the proximal third of each vessel. Donor age, male sex, and hypertension were the determinants of coronary atherosclerosis measured by IVUS examination. As more risk factors were present, the risk of atherosclerosis increased.Conclusion: Coronary atherosclerosis is common in asymptomatic young healthy adults, supporting the need for preventive cardiology in the early stages of life.
Authors:
Min-Seok Kim; Soo-Jin Kang; Cheol-Whan Lee; Seungbong Han; Duk-Woo Park; Seung-Whan Lee; Young-Hak Kim; Seong-Wook Park; Seung-Jung Park; Jae-Joong Kim
Related Documents :
23065469 - How should we treat multi-vessel disease in stemi patients?
19389719 - Clinical characteristics of patients with obstructive coronary lesions in the absence o...
16164659 - Effects of sevelamer and calcium on coronary artery calcification in patients new to he...
23351819 - Marijuana use and long-term mortality among survivors of acute myocardial infarction.
17284399 - Computed tomography angiography is an excellent tool for the diagnosis of congenital co...
6977269 - Ischemic heart disease in systemic lupus erythematosus in the young patient: report of ...
24561009 - Left ventricular lead position and outcomes in the resynchronization-defibrillation for...
8714499 - Proximal flow convergence method in the assessment of mitral stenosis.
303709 - Changes in hemodynamics and bradykinin concentration in coronary sinus blood in experim...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-05
Journal Detail:
Title:  Journal of atherosclerosis and thrombosis     Volume:  -     ISSN:  1880-3873     ISO Abbreviation:  J. Atheroscler. Thromb.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506298     Medline TA:  J Atheroscler Thromb     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Ultrasound Estimates for Midline Epidural Punctures in the Obese Parturient: Paramedian Sagittal Obl...
Next Document:  Target Uncertainty Does Not Lead To Greater Singleton Distractor Interference When Target Shapes Are...