Document Detail

Prevalence of congenital heart defects in newborns in Germany: Results of the first registration year of the PAN Study (July 2006 to June 2007).
MedLine Citation:
PMID:  20665366     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the current prevalence of congenital heart defects (CHD) in live births in Germany and to assess its relation to demographic and gestational parameters.
DESIGN: Nation-wide study (PAN: Praevalenz angeborener Herzfehler bei Neugeborenen) with passive registration of infants born between 1st July 2006 and 30th June 2007 in Germany diagnosed with CHD.
RESULTS: Data were provided by 260 participating institutions. 7 245 infants with CHD were registered to give a total CHD prevalence of 1.08%. The most common lesions were: ventricular septal defect (all types) (48.9%), atrial septal defect (17.0%), valvular pulmonary stenosis (6.1%), persistent arterial duct (4.3%) and aortic coarctation (3.6%). The most common cyanotic lesions were tetralogy of Fallot (2.5%) and complete transposition of the great arteries (2.2%). A single ventricle (all types) was identified in 2.8%, half of them being a hypoplastic left heart syndrome. Female gender was more common among mild CHD (57.3%) while there was a striking predominance of male infants among severe lesions (58.4%). Prematurity (18.7% vs. 9.1%), a birth weight below 2 500 g (17.5% vs. 6.8%) and multiple births (6.2% vs. 3.3%) were more frequent in infants with CHD than in all live births. More than 80% of the CHD diagnoses were made within three months after birth.
CONCLUSIONS: The PAN study recorded an overall CHD prevalence of 1.08% in Germany. The proportion of mild CHD may indicate a high diagnostic level, the prevalence of severe lesions is concordant with ranges reported by others. CHD is associated with prematurity, low birth weight and multiple births.
A Lindinger; G Schwedler; H-W Hense
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Publication Detail:
Type:  Journal Article     Date:  2010-07-21
Journal Detail:
Title:  Klinische Pädiatrie     Volume:  222     ISSN:  1439-3824     ISO Abbreviation:  Klin Padiatr     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-31     Completed Date:  2011-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326144     Medline TA:  Klin Padiatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  321-6     Citation Subset:  IM    
Copyright Information:
Georg Thieme Verlag KG Stuttgart, New York.
Clinic of Paediatric Cardiology, University Hospital, Homburg/Saar, Germany.
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MeSH Terms
Cross-Sectional Studies
Heart Defects, Congenital / epidemiology*
Infant, Low Birth Weight*
Infant, Newborn
Infant, Premature, Diseases / epidemiology*
Population Surveillance
Pregnancy, Multiple
Sex Factors
Comment In:
Klin Padiatr. 2010 Sep;222(5):281   [PMID:  20806164 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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