| Prevalence of congenital heart defects in newborns in Germany: Results of the first registration year of the PAN Study (July 2006 to June 2007). | |
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MedLine Citation:
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PMID: 20665366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the current prevalence of congenital heart defects (CHD) in live births in Germany and to assess its relation to demographic and gestational parameters. DESIGN: Nation-wide study (PAN: Praevalenz angeborener Herzfehler bei Neugeborenen) with passive registration of infants born between 1st July 2006 and 30th June 2007 in Germany diagnosed with CHD. RESULTS: Data were provided by 260 participating institutions. 7 245 infants with CHD were registered to give a total CHD prevalence of 1.08%. The most common lesions were: ventricular septal defect (all types) (48.9%), atrial septal defect (17.0%), valvular pulmonary stenosis (6.1%), persistent arterial duct (4.3%) and aortic coarctation (3.6%). The most common cyanotic lesions were tetralogy of Fallot (2.5%) and complete transposition of the great arteries (2.2%). A single ventricle (all types) was identified in 2.8%, half of them being a hypoplastic left heart syndrome. Female gender was more common among mild CHD (57.3%) while there was a striking predominance of male infants among severe lesions (58.4%). Prematurity (18.7% vs. 9.1%), a birth weight below 2 500 g (17.5% vs. 6.8%) and multiple births (6.2% vs. 3.3%) were more frequent in infants with CHD than in all live births. More than 80% of the CHD diagnoses were made within three months after birth. CONCLUSIONS: The PAN study recorded an overall CHD prevalence of 1.08% in Germany. The proportion of mild CHD may indicate a high diagnostic level, the prevalence of severe lesions is concordant with ranges reported by others. CHD is associated with prematurity, low birth weight and multiple births. |
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Authors:
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A Lindinger; G Schwedler; H-W Hense |
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Publication Detail:
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Type: Journal Article Date: 2010-07-21 |
Journal Detail:
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Title: Klinische Pädiatrie Volume: 222 ISSN: 1439-3824 ISO Abbreviation: Klin Padiatr Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-31 Completed Date: 2011-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0326144 Medline TA: Klin Padiatr Country: Germany |
Other Details:
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Languages: eng Pagination: 321-6 Citation Subset: IM |
Copyright Information:
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Georg Thieme Verlag KG Stuttgart, New York. |
Affiliation:
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Clinic of Paediatric Cardiology, University Hospital, Homburg/Saar, Germany. angelika.lindinger@uks.eu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cross-Sectional Studies Female Germany Heart Defects, Congenital / epidemiology* Humans Incidence Infant, Low Birth Weight* Infant, Newborn Infant, Premature, Diseases / epidemiology* Male Population Surveillance Pregnancy Pregnancy, Multiple Registries* Sex Factors |
| Comments/Corrections | |
Comment In:
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Klin Padiatr. 2010 Sep;222(5):281
[PMID:
20806164
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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