Document Detail

Prevalence and clinical outcome of polyvascular atherosclerotic disease in patients undergoing coronary intervention.
MedLine Citation:
PMID:  23018634     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The goal of this study was to evaluate the prevalence and outcomes of polyvascular disease (polyVD; defined as lower extremity artery disease, carotid artery disease, renal artery disease, or abdominal aortic aneurysm) in patients undergoing percutaneous coronary intervention (PCI).
METHODS AND RESULTS: The subjects were 1,597 patients who underwent PCI and who were prospectively enrolled in the study. The carotid, renal and peripheral arteries and abdominal aorta were simultaneously evaluated using duplex ultrasound and ankle-brachial index to evaluate the presence of polyVD. The primary endpoint was major adverse cardiovascular events (MACE: cardiovascular death, myocardial infarction [MI], and stroke). PolyVD was found in 446 of 1,597 patients (27.9%). MACE were significantly higher in the polyVD group compared to those with coronary artery disease (CAD) alone (n=1,151; 12.1% vs. 3.8%, P<0.0001). The incidence of cardiovascular death and stroke were significantly higher in the polyVD group (7.9% vs. 1.6%, P<0.0001; 3.6% vs. 1.2%, P=0.006, respectively). The incidence of MI was similar in the 2 groups (3.7% vs. 1.3%, P=0.08). The adjusted hazard ratios for MACE in patients with 1, 2, and 3 arterial beds (compared with CAD alone) increased from 1.64 to 1.74 to 10.62 (P<0.0001).
CONCLUSIONS: There was a high incidence of MACE in patients with polyVD undergoing PCI and this incidence increased with the number of arterial beds.
Takashi Miura; Yoshimitsu Soga; Tatsuki Doijiri; Hideaki Aihara; Hiroyoshi Yokoi; Masashi Iwabuchi; Masakiyo Nobuyoshi
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2012-09-26
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  77     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-07     Completed Date:  2013-06-13     Revised Date:  2013-07-08    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  89-95     Citation Subset:  IM    
Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan. miuramen10
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MeSH Terms
Aged, 80 and over
Atherosclerosis / diagnosis*,  mortality*,  surgery*
Middle Aged
Percutaneous Coronary Intervention*
Comment In:
Circ J. 2013;77(1):43-4   [PMID:  23131761 ]
Circ J. 2013;77(5):1349   [PMID:  23449373 ]
Circ J. 2013;77(5):1348   [PMID:  23449372 ]

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