Document Detail


Prevalence of chronic kidney disease in persons with undiagnosed or prehypertension in the United States.
MedLine Citation:
PMID:  20308607     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypertension is both a cause and a consequence of chronic kidney disease, but the prevalence of chronic kidney disease throughout the diagnostic spectrum of blood pressure has not been established. We determined the prevalence of chronic kidney disease within blood pressure categories in 17 794 adults surveyed by the National Health and Nutrition Examination Survey during 1999-2006. Diagnosed hypertension was defined as self-reported provider diagnosis (n=5832); undiagnosed hypertension was defined as systolic blood pressure > or = 140 mm Hg or diastolic blood pressure > or = 90 mm Hg, without report of provider diagnosis (n=3046); prehypertension was defined as systolic blood pressure > or = 120 and <140 mm Hg or diastolic blood pressure > or = 80 and <90 mm Hg (n=3719); and normal was defined as systolic blood pressure <120 mm Hg and diastolic blood pressure <80 mm Hg (n=5197). Chronic kidney disease was defined as estimated glomerular filtration rate <60 mL/min per 1.73 m(2) or urinary albumin:creatinine ratio >30 mg/g. Prevalences of chronic kidney disease among those with prehypertension and undiagnosed hypertension were 17.3% and 22.0%, respectively, compared with 27.5% with diagnosed hypertension and 13.4% with normal blood pressure, after adjustment for age, sex, and race in multivariable logistic regression. This pattern persisted with varying definitions of kidney disease; macroalbuminuria (urinary albumin:creatinine ratio >300 mg/g) had the strongest association with increasing blood pressure category (odds ratio: 2.37 [95% CI: 2.00 to 2.81]). Chronic kidney disease is prevalent in undiagnosed and prehypertension. Earlier identification and treatment of both these conditions may prevent or delay morbidity and mortality from chronic kidney disease.
Authors:
Deidra C Crews; Laura C Plantinga; Edgar R Miller; Rajiv Saran; Elizabeth Hedgeman; Sharon H Saydah; Desmond E Williams; Neil R Powe;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2010-03-22
Journal Detail:
Title:  Hypertension     Volume:  55     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-15     Completed Date:  2010-05-28     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1102-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure
Continental Population Groups
Ethnic Groups
Female
Glomerular Filtration Rate
Humans
Hypertension / complications,  epidemiology*
Kidney
Kidney Failure, Chronic / classification,  complications,  epidemiology*
Male
Nutrition Surveys
Prevalence
United States / epidemiology
Grant Support
ID/Acronym/Agency:
K24 DK002643/DK/NIDDK NIH HHS; K24 DK002643-11/DK/NIDDK NIH HHS; K24DK02643/DK/NIDDK NIH HHS; R01 DK080123/DK/NIDDK NIH HHS; U36/CCU319276//PHS HHS
Investigator
Investigator/Affiliation:
Neil Powe / ; Laura Plantinga / ; Kirsten Bibbins-Domingo / ; Josef Coresh / ; Alan Go / ; Chi-yuan Hsu / ; Lesley Stevens / ; Deidra Crews / ; Matthew Ong / ; Rajiv Saran / ; Elizabeth Hedgeman / ; Brenda Gillespie / ; William Herman / ; Friedrich Port / ; Bruce Robinson / ; Vahakn Shahinian / ; Jerry Yee / ; Eric Young / ; Desmond Williams / ; Nilka Rios Burrows / ; Mark Eberhardt / ; Paul Eggers / ; Linda Geiss / ; Susan Hailpern / ; Regina Jordan / ; Juanita Mondeshire / ; Bernice Moore / ; Gary Myers / ; Meda Pavkov / ; Deborah Rolka / ; Sharon Saydah / ; Anton Schoolwerth / ; Rodolfo Valdez / ; Larry Waller /
Comments/Corrections
Comment In:
Hypertension. 2010 May;55(5):1097-9   [PMID:  20308606 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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