Document Detail


Prevalence, characteristics and perinatal outcome of fetal ventriculomegaly in 29,000 pregnancies followed at a single institution.
MedLine Citation:
PMID:  20339298     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Our purpose was to assess the impact of prenatally diagnosed ventriculomegaly (VM) on the course of advancing pregnancy and the postnatal outcome of affected fetuses. METHODS: In this retrospective survey 109/28,935 (3.8 per 1,000) singleton pregnancies with abnormal width of the fetal lateral ventricle system diagnosed by antenatal ultrasound examination at the University Hospital of Schleswig-Holstein, Campus Lübeck, were reviewed between 1993 and 2007. Clinical data and pregnancy outcome information were derived from a standardized parental questionnaire or from hospital records. Postnatal follow-up was obtained in >90%. RESULTS: Forty-seven cases with isolated VM (IVM; 43%) and 62 fetuses (57%) with nonisolated VM were diagnosed. In the IVM group 19 cases had mild and 28 fetuses severe VM. Of 62 cases with non-IVM there were 32 with mildly dilated ventricles and 30 had severe enlargements. Chromosomal aberrations were present in 5 fetuses (4.6%) of the non-IVM group. Thirty-four pregnancies (31%) were terminated on parental request (10 IVM/24 non-IVM). The risk of abnormal neurodevelopmental outcome was highest in the presence of associated anomalies (irrespective of the extent of dilatation) and in cases with severe IVM (91 and 68%, respectively). In contrast, 13/14 children with mild IVM showed an age-related normal psychomotor behavior. Fetuses with severe VM had a 2.2- (IVM) to 3.6-fold (non-IVM) elevated risk of progressive dilatations compared to mild VM. In our study the fetuses with asymmetrical bilateral IVM tended to have severe ventricular enlargements more often. CONCLUSIONS: As reported previously we found a positive association between neurodevelopmental delay and the degree of lateral ventricular dilatation. The presence of additional abnormalities is generally a poor prognostic sign and accompanied by a nonfavorable postnatal outcome.
Authors:
Jan Weichert; D Hartge; M Krapp; U Germer; U Gembruch; Roland Axt-Fliedner
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Publication Detail:
Type:  Journal Article     Date:  2010-03-26
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  27     ISSN:  1421-9964     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-23     Completed Date:  2010-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  142-8     Citation Subset:  IM    
Copyright Information:
Copyright 2010 S. Karger AG, Basel.
Affiliation:
Division of Prenatal Medicine, University of Schleswig-Holstein, Campus Lübeck, Lübeck, Germany. weichertj@web.de
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Cerebral Ventricles / abnormalities*,  ultrasonography
Chromosome Aberrations
Dilatation, Pathologic / epidemiology,  ultrasonography
Female
Germany / epidemiology
Humans
Infant
Infant Mortality
Infant, Newborn
Middle Aged
Perinatal Mortality
Pregnancy
Pregnancy Outcome / epidemiology
Prevalence
Prognosis
Psychomotor Performance
Retrospective Studies
Ultrasonography, Prenatal
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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