| Prevalence and Characteristics of Early Repolarization in the CASPER Registry Cardiac Arrest Survivors With Preserved Ejection Fraction Registry. | |
| | |
MedLine Citation:
|
PMID: 21816308 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVES: We evaluated the prevalence and characteristics of early repolarization in patients in CASPER (Cardiac Arrest Survivors With Preserved Ejection Fraction Registry). BACKGROUND: Early repolarization has been implicated in a syndrome of polymorphic ventricular tachycardia and fibrillation in patients without organic heart disease. METHODS: One hundred patients with apparently unexplained cardiac arrest and preserved ejection fraction underwent extensive clinical and genetic testing to unmask subclinical electrical or structural disease. A blinded independent analysis of the 12-lead electrocardiogram (ECG) was performed. Early repolarization was defined as ≥0.1 mV QRS-ST junction (J-point) elevation with terminal QRS slurring or notching in at least 2 contiguous inferior and/or lateral leads. RESULTS: One hundred cardiac arrest patients were enrolled (40 females, age 43 ± 14 years). Forty-four were diagnosed with an established cause for cardiac arrest. Significant early repolarization was found in 19 patients, including 6 with a primary diagnosis that explained their cardiac arrest (14%), compared with 23% of the 56 patients with idiopathic ventricular fibrillation (IVF) (p = 0.23). J-point elevation in IVF patients had higher amplitude (0.25 ± 0.11 mV vs. 0.13 ± 0.05 mV, p = 0.02) and wider distribution (4.3 ± 1.3 leads vs. 2.8 ± 0.8 leads; p = 0.01) than those with an established cause of cardiac arrest. J-wave amplitude was fluctuant on serial ECGs; at least 1 ECG failed to demonstrate early repolarization in 58% of patients. CONCLUSIONS: Early repolarization is present in a significant proportion of causally diagnosed and idiopathic VF. It is often intermittent and more pronounced in IVF patients. (Registry of Unexplained Cardiac Arrest; NCT00292032). |
| | |
Authors:
|
Nicolas Derval; Christopher S Simpson; David H Birnie; Jeffrey S Healey; Vijay Chauhan; Jean Champagne; Martin Gardner; Shubhayan Sanatani; Raymond Yee; Allan C Skanes; Lorne J Gula; Peter Leong-Sit; Kamran Ahmad; Michael H Gollob; Michel Haïssaguerre; George J Klein; Andrew D Krahn |
Related Documents
:
|
22440888 - Cardioprotection during cardiac surgery. 8891468 - Lisinopril. a review of its pharmacology and clinical efficacy in the early management ... 22421228 - Natural history of coronary atherosclerosis by multislice computed tomography. 699938 - Intravenous and oral practolol in the acute stages of myocardial infarction. 6354078 - Comparison of cephalothin and ceforanide prophylaxis in cardiac surgery with cardiopulm... 12637368 - Ets-1 and ets-2 transcription factors are essential for normal coronary and myocardial ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of the American College of Cardiology Volume: 58 ISSN: 1558-3597 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-08-05 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 722-8 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Hopital Haut Lévêque, CHU Bordeaux, University Bordeaux 2, Bordeaux, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Transapical transcatheter aortic valve implantation in the presence of a mitral prosthesis.
Next Document: Reduction of the Risk of Recurring Heart Failure Events With Cardiac Resynchronization Therapy MADIT...