Document Detail


The Prevalence Of Cervical Regulatory T Cells in HPV-Related Cervical Intraepithelial Neoplasia (CIN) Correlates Inversely with Spontaneous Regression of CIN.
MedLine Citation:
PMID:  23057776     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PROBLEM: Local adaptive cervical regulatory T cells (Tregs) are the most likely direct suppressors of the immune eradication of cervical intraepithelial lesion (CIN). PD-1 expression on T cells induces Tregs. No studies have quantitatively analyzed the Tregs and PD-1+ cells residing in CIN lesions. METHOD OF STUDY: Cervical lymphocytes were collected using cytobrushes from CIN patients and analyzed by FACS analysis. Comparisons were made between populations of cervical Tregs and PD-1+ CD4+ T cells in CIN regressors and non-regressors. RESULTS: A median of 11% of cervical CD4+ T cells were Tregs, while a median of 30% were PD-1+ cells. The proportions of cervical CD4+ T cells that were Tregs and/or PD-1+ cells were significantly lower in CIN regressors when compared with non-regressors. CONCLUSIONS: The prevalence of cervical tolerogenic T cells correlates inversely with spontaneous regression of CIN. Cervical Tregs may play an important role in HPV-related neoplastic immunoevasion.
Authors:
Satoko Kojima; Kei Kawana; Kensuke Tomio; Aki Yamashita; Ayumi Taguchi; Shiho Miura; Katsuyuki Adachi; Takeshi Nagamatsu; Kazunori Nagasaka; Yoko Matsumoto; Takahide Arimoto; Katsutoshi Oda; Osamu Wada-Hiraike; Tetsu Yano; Yuji Taketani; Tomoyuki Fujii; Danny J Schust; Shiro Kozuma
Related Documents :
24225196 - Novel biologically-inspired rosette nanotube plla scaffolds for improving human mesench...
23070776 - Flow cytometry-based cell type-specific assessment of target regulation by pulmonary si...
23046996 - Autofluorescence contributes to false-positive intracellular foxp3 staining in macropha...
23296906 - Involvement of (igg and igm)-secreting b lymphocytes in severity of autoimmune hepatiti...
6088626 - Role of the thymus in control of autoreactivity or allotolerance in syngeneic and allog...
22689946 - Presensitizing with a toll-like receptor 3 ligand impairs cd8 t-cell effector different...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-11
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  -     ISSN:  1600-0897     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Affiliation:
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Formation of Fe2O3 Microboxes with Hierarchical Shell Structures from Metal-organic Frameworks and T...
Next Document:  The Nephroprotective Properties of Recombinant Human Erythropoietin in Kidney Transplantation: Exper...