Document Detail


Prevalence of CYP2C9 and VKORC1 mutation in patients with valvular heart disease in northern Thailand.
MedLine Citation:
PMID:  20043560     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Warfarin has been widely used for the prevention and treatment of thromboembolism. Warfarin therapy depends on interaction between physiological, environmental, and genetic factors. Vitamin K epoxide reductase (VKORC1) and cytochrome P450 2C9 (CYP2C9) enzyme conjointly determine the warfarin maintenance dose. The prevalence of CYP2C9 and VKORC1 variants varies among ethnic groups. The purpose of the present study was to investigate the prevalence of CYP2C and VKORC1 in the Northern Thai population.
MATERIAL AND METHOD: Patients with valvular heart disease who regularly took a steady maintenance warfarin dose for at least one month were recruited into the present study. Patients who had taken amiodarone or an anti-inflammatory drug were excluded Clinical data were obtained from medical records. Five milliliters of whole blood was drawn from each patient for gene analysis and prothrombin time with international normalized ratio (INR) measurement.
RESULTS: From 242 patients, CYP2C9 *1/*1 was found in 230 patients (95%) and CYP2C9 *1/*3 was found in 12 patients (5%). Neither mutant CYP2C9*2 allele nor individuals homozygous for CYP2C9*3 were observed. Regarding VKORC1, haplotype AB was found in 83 patients (34.3%) and haplotype AA was found in 154 patients (63.6%). Haplotype BB (wild type) was found in five patients (2.1%).
CONCLUSION: The prevalence of CYP2C9 *1/*1 is high while the prevalence of CYP2C9*2 and CYP2C9*3 is very low. VKORC1 haplotype AA is the most common among the Northern Thai population. Further study regarding pharmacogenetic and non-genetic factors to develop warfarin-dosing algorithm is warranted
Authors:
Srun Kuanprasert; Sakchai Dettrairat; Poonsub Palacajornsuk; Warunee Kunachiwa; Arintaya Phrommintikul
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  92     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-01-01     Completed Date:  2011-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  1597-601     Citation Subset:  IM    
Affiliation:
Department of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50210, Thailand.
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MeSH Terms
Descriptor/Qualifier:
Anticoagulants / therapeutic use*
Aryl Hydrocarbon Hydroxylases / genetics*
Female
Heart Valve Diseases / drug therapy,  epidemiology,  genetics*
Humans
International Normalized Ratio
Male
Middle Aged
Mixed Function Oxygenases / genetics*
Mutation
Pharmacogenetics
Polymorphism, Genetic
Prevalence
Risk Factors
Thailand / epidemiology
Warfarin / therapeutic use*
Chemical
Reg. No./Substance:
0/Anticoagulants; 81-81-2/Warfarin; EC 1.-/Mixed Function Oxygenases; EC 1.14.14.1/Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1/CYP2C9 protein, human; EC 1.14.99.-/vitamin K epoxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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