| Prevalence of CT-detected cerebral abnormalities in an elderly Swedish population sample. | |
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MedLine Citation:
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PMID: 18336623 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To measure the prevalence of computed tomography (CT)-detected cerebral lesions in a population-based sample of elderly persons living in Göteborg, Sweden. METHODS: Cerebral CT-scans were performed in the case of 466 women (mean age 74.3 +/- 5.1 years) and 191 70-year-old men. A single rater assessed white matter lesions (WML) using four different scales, lacunar lesions, large infarcts, cortical atrophy, and basal ganglia calcifications. RESULTS: White matter lesions frequency assessed by different scales ranged between 54.5% and 68.5%. Lacunar lesions were detected in 46.7% (30.1% had lacunes >5 mm) and cerebral infarcts in 3.0% of participants. Overall, 72.8% of participants evidenced cerebral vascular abnormalities. Severe cortical atrophy was more common in temporal (6.4%) and frontal (6.7%) lobes, than in parietal (1.7%) and occipital (1.1%) lobes. Basal ganglia calcifications were found in 38.7% of participants. WML, lacunar lesions, large infarcts, and degree of cortical atrophy correlated positively with age. More lacunes, basal ganglia calcifications, and occipital lobe atrophy were associated with male gender. CONCLUSIONS: Vascular and other brain lesions are very common on CT-scan in an elderly population, but large vascular lesions are rare. This study provides the first reference for the prevalence of CT-detected abnormalities in an elderly Swedish population. |
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Authors:
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M Simoni; L Pantoni; G Pracucci; B Palmertz; X Guo; D Gustafson; I Skoog |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-03-11 |
Journal Detail:
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Title: Acta neurologica Scandinavica Volume: 118 ISSN: 1600-0404 ISO Abbreviation: Acta Neurol. Scand. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-29 Completed Date: 2008-11-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370336 Medline TA: Acta Neurol Scand Country: Denmark |
Other Details:
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Languages: eng Pagination: 260-7 Citation Subset: IM |
Affiliation:
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Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Brain Diseases / epidemiology*, pathology, radiography* Cerebral Cortex / blood supply, pathology, radiography* Cerebrovascular Circulation / physiology Female Humans Male Prevalence Sweden Tomography, X-Ray Computed* |
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