Document Detail

Prevalence of Behcet's disease among adult patients consulting three major clinics in a Druze town in Israel.
MedLine Citation:
PMID:  20467881     Owner:  NLM     Status:  MEDLINE    
To evaluate the prevalence of Behçet's disease (BD) in a Druze community in Israel, we conducted a two-stage clinic-based survey in an Israeli Druze town. The first stage aimed to identify patients with recurrent aphthous stomatitis (RAS) in all patients who visited three of the largest clinics in the town during a period of 6 months. The second stage aimed to identify those patients with RAS who fulfilled the diagnostic criteria for BD according to the International Study Group (ISG) criteria. One thousand and eighty-three out of about 4,000 registered subjects were interviewed, 63 of whom had RAS (5.8%). Two patients fulfilled the ISG criteria for BD, resulting in a calculated prevalence in the range of 2:1,083-2:4,000, i.e., 50-185:100,000. Another two patients with oral and genital aphthosis but without eye or skin lesions were diagnosed as suspected BD. The very high prevalence of BD, as found in our study, places the Druze among the populations with the highest prevalence of the disease all over the world, though selection biases could account for overestimation as well as underestimation of the actual BD prevalence. Our findings call for genetic studies to explore whether there is a genetic predisposition to BD in this population.
Pinchas Klein; Abraham Weinberger; Vered Jean Altmann; Salim Halabi; Saeed Fachereldeen; Ilan Krause
Publication Detail:
Type:  Journal Article     Date:  2010-05-14
Journal Detail:
Title:  Clinical rheumatology     Volume:  29     ISSN:  1434-9949     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-08-30     Completed Date:  2010-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1163-6     Citation Subset:  IM    
Department of Internal Medicine B, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel.
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MeSH Terms
Behcet Syndrome / diagnosis,  epidemiology*
Chi-Square Distribution
Israel / epidemiology
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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