Document Detail


Prevalence of Barrett esophagus in first-degree relatives of patients with esophageal adenocarcinoma.
MedLine Citation:
PMID:  21617543     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: The aim of this study is to determine the prevalence of Barrett esophagus (BE) in first-degree relatives of patients with esophageal adenocarcinoma (EAC) and Barrett high-grade dysplasia (HGD).
METHODS: After Institutional Review Board approval, first-degree relatives of patients with EAC/HGD underwent unsedated ultrathin transnasal endoscopy (UUTNE) with biopsy. BE was suspected if any salmon-colored epithelial tongues were seen above the gastroesophageal junction. A diagnosis of BE was made only if biopsy from these areas confirmed columnar-lined epithelium with intestinal metaplasia.
RESULTS: From 23 families, 47 first-degree relatives underwent ultrathin transnasal endoscopy and 1 patient underwent routine upper endoscopy with sedation as part of this study. The mean age of cases was 44.4 years. All patients tolerated the procedure well and there were no procedure-related complications. BE was suspected in 16 (34%) patients and confirmed in 13 of 16 (27.7%) patients. There were 4 long segments (>3 cm) and 9 short segments (<3 cm) of BE.
CONCLUSION: There is a significantly higher than expected prevalence of BE in first-degree relatives of patients with EAC/HGD. This should be taken in to consideration to develop further screening guidelines. Further work is needed to confirm these findings. Unsedated transnasal endoscopy is a safe and well-tolerated method for BE screening.
Authors:
Arpad Juhasz; Sumeet K Mittal; Tommy H Lee; Caishu Deng; Amitabh Chak; Henry T Lynch
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  45     ISSN:  1539-2031     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:    2011 Nov-Dec
Date Detail:
Created Date:  2011-10-12     Completed Date:  2012-02-02     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  867-71     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / epidemiology*,  genetics
Adult
Aged
Aged, 80 and over
Barrett Esophagus / diagnosis,  epidemiology*,  genetics
Biopsy
Endoscopy, Digestive System / adverse effects,  methods*
Esophageal Neoplasms / epidemiology*,  genetics
Family
Female
Humans
Male
Middle Aged
Prevalence
Grant Support
ID/Acronym/Agency:
R01 DK070863/DK/NIDDK NIH HHS; R01 DK070863-04S1/DK/NIDDK NIH HHS; R01DK070863/DK/NIDDK NIH HHS
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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