| Prevalence of Barrett esophagus in first-degree relatives of patients with esophageal adenocarcinoma. | |
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MedLine Citation:
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PMID: 21617543 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The aim of this study is to determine the prevalence of Barrett esophagus (BE) in first-degree relatives of patients with esophageal adenocarcinoma (EAC) and Barrett high-grade dysplasia (HGD). METHODS: After Institutional Review Board approval, first-degree relatives of patients with EAC/HGD underwent unsedated ultrathin transnasal endoscopy (UUTNE) with biopsy. BE was suspected if any salmon-colored epithelial tongues were seen above the gastroesophageal junction. A diagnosis of BE was made only if biopsy from these areas confirmed columnar-lined epithelium with intestinal metaplasia. RESULTS: From 23 families, 47 first-degree relatives underwent ultrathin transnasal endoscopy and 1 patient underwent routine upper endoscopy with sedation as part of this study. The mean age of cases was 44.4 years. All patients tolerated the procedure well and there were no procedure-related complications. BE was suspected in 16 (34%) patients and confirmed in 13 of 16 (27.7%) patients. There were 4 long segments (>3 cm) and 9 short segments (<3 cm) of BE. CONCLUSION: There is a significantly higher than expected prevalence of BE in first-degree relatives of patients with EAC/HGD. This should be taken in to consideration to develop further screening guidelines. Further work is needed to confirm these findings. Unsedated transnasal endoscopy is a safe and well-tolerated method for BE screening. |
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Authors:
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Arpad Juhasz; Sumeet K Mittal; Tommy H Lee; Caishu Deng; Amitabh Chak; Henry T Lynch |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of clinical gastroenterology Volume: 45 ISSN: 1539-2031 ISO Abbreviation: J. Clin. Gastroenterol. Publication Date: 2011 Nov-Dec |
Date Detail:
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Created Date: 2011-10-12 Completed Date: 2012-02-02 Revised Date: 2013-02-19 |
Medline Journal Info:
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Nlm Unique ID: 7910017 Medline TA: J Clin Gastroenterol Country: United States |
Other Details:
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Languages: eng Pagination: 867-71 Citation Subset: IM |
Affiliation:
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Department of Surgery, Creighton University Medical Center, Omaha, NE, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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epidemiology*,
genetics Adult Aged Aged, 80 and over Barrett Esophagus / diagnosis, epidemiology*, genetics Biopsy Endoscopy, Digestive System / adverse effects, methods* Esophageal Neoplasms / epidemiology*, genetics Family Female Humans Male Middle Aged Prevalence |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK070863-04S1/DK/NIDDK NIH HHS; R01DK070863/DK/NIDDK NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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