Document Detail


Prevalence, Associated Risk Factors and Effects of Hypothyroidism in Pregnancy: A Study from North India.
MedLine Citation:
PMID:  22738929     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background and Objective: There is a controversy regarding universal versus targeted screening for hypothyroidism during pregnancy. We studied the prevalence and the associated risk factors of hypothyroidism. The secondary objective of the study was to compare the maternal and perinatal outcomes in overt and subclinical hypothyroidism. Methods: We screened 1,005 antenatal patients for hypothyroidism with a thyrotropin assay. Patients diagnosed with hypothyroidism were further tested for anti-thyroid peroxidase antibodies and free thyroxin to determine the cause and type (overt or subclinical) of hypothyroidism. Maternal and perinatal outcomes were compared in the overt, subclinical and euthyroid groups. Results: The overall prevalence of hypothyroidism was 6.3% (overt 2.9% and subclinical 3.4%). Thirty-four (3.4%) new hypothyroid cases could be detected by universal screening. The risk factors for thyroid dysfunction were not significantly different in the screen-positive versus screen-negative patients except for excessive weight gain (p = 0.00). Targeted screening could have missed one third of subclinical hypothyroid cases. Gestational hypertension was significantly greater in the overt hypothyroid group (p = 0.007), and more patients required induction in this group (p = 0.013) but other maternal complications and perinatal outcomes were similar. Conclusion: We recommend universal screening for hypothyroidism in pregnancy in our population, as the prevalence of hypothyroidism is high.
Authors:
Poonam Goel; Jasbinder Kaur; Pradip Kumar Saha; Rimpy Tandon; Lajjya Devi
Related Documents :
7537879 - The influence of gravidity on down's syndrome screening with free beta hcg.
8446569 - Prospective maternal serum human chorionic gonadotropin screening for the risk of fetal...
7682319 - Ectopic pregnancy with undetectable serum and urine beta-hcg levels and detection of be...
7468689 - A protein-binding radioassay for 6 beta-hydroxycortisol: detection in pregnancy urine a...
2437799 - Declining serum concentrations of the beta-subunit of human chorionic gonadotropin and ...
3354549 - Evaluation of methods for the prospective identification of early fetal losses in envir...
21450029 - Two cases of angular pregnancy complicated by preterm labor and placental abruption at ...
15705619 - Ivf versus icsi in sibling oocytes from patients with polycystic ovarian syndrome: a ra...
19848299 - Conceptus-uterus interactions in pigs: endometrial gene expression in response to estro...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-23
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  -     ISSN:  1423-002X     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Affiliation:
Department of Obstetrics and Gynecology, Government Medical College and Hospital, Chandigarh, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Repeated sorption of water in SBA-15 investigated by means of in situ small-angle x-ray scattering.
Next Document:  Memory Impairment, in Mild Cognitive Impairment without Significant Cerebrovascular Disease, Predict...