| Pretruncal subarachnoid hemorrhage and high cerebral blood flow velocities with bevacizumab therapy. | |
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MedLine Citation:
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PMID: 20864839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We describe the case of a 55-year-old woman with metastatic colorectal cancer, treated with bevacizumab, who developed sudden occipital pain, with nausea, vomiting, mild confusion, and signs of meningeal irritation. Imaging studies (computed tomographic scan and magnetic resonance imaging) revealed a pretruncal subarachnoid hemorrhage without an underlying vascular malformation; transcranial Doppler carried out 24 hours after the clinical onset showed increased blood flow velocities, mainly in the right middle cerebral artery. The neurological and hemodynamic alterations resolved with medical treatment within 10 days. Bevacizumab is a humanized monoclonal antibody that inhibits the vascular endothelial growth factor. The potential role of anti-vascular endothelial growth factor treatment on the subarachnoid hemorrhage and increased cerebral blood flow velocities is discussed. |
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Authors:
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José Fidel Baizabal-Carvallo; Marlene Alonso-Juárez; Irving Salas |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical neuropharmacology Volume: 33 ISSN: 1537-162X ISO Abbreviation: Clin Neuropharmacol Publication Date: 2010 Sep-Oct |
Date Detail:
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Created Date: 2010-09-24 Completed Date: 2011-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7607910 Medline TA: Clin Neuropharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 268-9 Citation Subset: IM |
Affiliation:
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Assistance Publique des Hôpitaux de Paris (APHP). Fédération de Neurologie, and Urgences Cerebrovasculaires, Groupe Hospitalier Pitié-Salpêtrière, Paris, France. baicarjf@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiogenesis Inhibitors
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adverse effects* Antibodies, Monoclonal / adverse effects* Blood Flow Velocity / drug effects Cerebral Angiography Cerebral Arteries / drug effects*, radiography Colorectal Neoplasms / drug therapy Female Humans Magnetic Resonance Imaging Middle Aged Subarachnoid Hemorrhage / etiology*, physiopathology Tomography, X-Ray Computed Ultrasonography, Doppler, Transcranial |
| Chemical | |
Reg. No./Substance:
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0/Angiogenesis Inhibitors; 0/Antibodies, Monoclonal; 0/bevacizumab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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