Document Detail

Pretreatment with stellate ganglion blockade before ischemia reduces infarct size in rat hearts.
MedLine Citation:
PMID:  20174729     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the role of stellate ganglion blockade (SGB) in cardio-protection against ischemia reperfusion injury. METHODS: This prospective randomized, experimental study was carried out between August and October 2008 in the Department of Anesthesia, Abant Izzet Baysal University, Bolu, Turkey. Twenty-one rats were randomly divided into 3 groups; group 1--SGB group (rats with percutaneous ganglion blockade), group 2--preconditioned (P) group (rats that were subjected to ischemia and then reperfusion periods for 5 minutes), and group 3--control group (rats that were injected with normal saline). RESULTS: During the ligation period, the length of arrhythmia was significantly shorter in group 2 compared with group 3 (p<0.001). The arrhythmia score in groups 1 and 2 was significantly lower compared with group 3 (p<0.001). In the reperfusion period, the length of arrhythmia was not significantly different in all study groups (p>0.05). But the arrhythmia score was significantly lower both in group 1 and group 3, compared with group 2 (p<0.02). Both in the ischemic and reperfusion periods, the incidence of arrhythmia was lowest in group 1. The infarct size was measured significantly less in groups 1 and 2 compared with group 3 (p<0.001). CONCLUSION: Pretreatment with the left SGB leads to lower arrhythmia scores and reduced infarct size in the Langendorff-perfused rat hearts compared with group 3, but not with group 2.
Nebahat Gulcu-Bulut; Ersoz Gonca; Hasan Kocoglu; Omer Bozdogan; Kazim Karaaslan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Saudi medical journal     Volume:  31     ISSN:  0379-5284     ISO Abbreviation:  Saudi Med J     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-22     Completed Date:  2010-06-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909441     Medline TA:  Saudi Med J     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  148-52     Citation Subset:  IM    
Department of Anesthesiology, Medical Faculty, Abant Izzet Baysal University, Bolu 14280, Turkey.
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MeSH Terms
Ischemic Preconditioning, Myocardial*
Myocardial Infarction / pathology,  prevention & control*
Rats, Sprague-Dawley
Stellate Ganglion*

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