| Pretreatment with stellate ganglion blockade before ischemia reduces infarct size in rat hearts. | |
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MedLine Citation:
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PMID: 20174729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the role of stellate ganglion blockade (SGB) in cardio-protection against ischemia reperfusion injury. METHODS: This prospective randomized, experimental study was carried out between August and October 2008 in the Department of Anesthesia, Abant Izzet Baysal University, Bolu, Turkey. Twenty-one rats were randomly divided into 3 groups; group 1--SGB group (rats with percutaneous ganglion blockade), group 2--preconditioned (P) group (rats that were subjected to ischemia and then reperfusion periods for 5 minutes), and group 3--control group (rats that were injected with normal saline). RESULTS: During the ligation period, the length of arrhythmia was significantly shorter in group 2 compared with group 3 (p<0.001). The arrhythmia score in groups 1 and 2 was significantly lower compared with group 3 (p<0.001). In the reperfusion period, the length of arrhythmia was not significantly different in all study groups (p>0.05). But the arrhythmia score was significantly lower both in group 1 and group 3, compared with group 2 (p<0.02). Both in the ischemic and reperfusion periods, the incidence of arrhythmia was lowest in group 1. The infarct size was measured significantly less in groups 1 and 2 compared with group 3 (p<0.001). CONCLUSION: Pretreatment with the left SGB leads to lower arrhythmia scores and reduced infarct size in the Langendorff-perfused rat hearts compared with group 3, but not with group 2. |
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Authors:
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Nebahat Gulcu-Bulut; Ersoz Gonca; Hasan Kocoglu; Omer Bozdogan; Kazim Karaaslan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Saudi medical journal Volume: 31 ISSN: 0379-5284 ISO Abbreviation: Saudi Med J Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-22 Completed Date: 2010-06-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909441 Medline TA: Saudi Med J Country: Saudi Arabia |
Other Details:
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Languages: eng Pagination: 148-52 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Medical Faculty, Abant Izzet Baysal University, Bolu 14280, Turkey. gulcune@yahoo.com.tr |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ischemic Preconditioning, Myocardial* Male Myocardial Infarction / pathology, prevention & control* Rats Rats, Sprague-Dawley Stellate Ganglion* |
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