| Pretreatment with perfluorohexane vapor attenuates fMLP-induced lung injury in isolated perfused rabbit lungs. | |
| | |
MedLine Citation:
|
PMID: 20653469 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The authors investigated the protective effects and dose dependency of perfluorohexane (PFH) vapor on leukocyte-mediated lung injury in isolated, perfused, and ventilated rabbit lungs. Lungs received either 18 vol.% (n = 7), 9 vol.% (n = 7), or 4.5 vol.% (n = 7) PFH. Fifteen minutes after beginning of PFH application, lung injury was induced with formyl-Met-Leu-Phe (fMLP). Control lungs (n = 7) received fMLP only. In addition 5 lungs (PFH-sham) remained uninjured receiving 18 vol.% PFH only. Pulmonary artery pressure (mPAP), peak inspiratory pressure (P(max)), and lung weight were monitored for 90 minutes. Perfusate samples were taken at regular intervals for analysis and representative lungs were fixed for histological analysis. In the control, fMLP application led to a significant increase of mPAP, P(max), lung weight, and lipid mediators. Pretreatment with PFH attenuated the rise in these parameters. This was accompanied by preservation of the structural integrity of the alveolar architecture and air-blood barrier. In uninjured lungs, mPAP, P(max), lung weight, and lipid mediator formation remained uneffected in the presence of PFH. The authors concluded that pretreatment with PFH vapor leads to an attenuation of leukocyte-mediated lung injury. Vaporization of perfluorocarbons (PFCs) offers new therapeutic options, making use of their protective and anti-inflammatory properties in prophylaxis or in early treatment of acute lung injury. |
| | |
Authors:
|
Jörg U Bleyl; Axel R Heller; Antonia Fehrenbach; Manuel Heintz; Heinz Fehrenbach; Gesa Klenz; Marcelo Gama de Abreu; Matthias Hübler; Peter M Spieth; Thea Koch |
Related Documents
:
|
1986399 - Early radiation response of the canine heart and lung. 3487339 - Lung mechanics, radiography and 67ga scintigraphy in experimental pneumocystis carinii ... 11172579 - Lung recruitment. 8567579 - Effects of ventilation and pleural effusion on measurements of airway thermal volume an... 1141099 - Lung mechanics in hypervolemic pulmonary edema. 7118649 - Changes in collateral ventilation with increased vascular pressure and edema formation. 6811959 - The effects of molsidomine on intracranial pressure in anaesthetized dogs. 3306209 - Essential hypertension: neural considerations. 18363579 - Changes in colloid osmotic pressure as a function of anesthesia and surgery in the pres... |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Experimental lung research Volume: 36 ISSN: 1521-0499 ISO Abbreviation: Exp. Lung Res. Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-07-26 Completed Date: 2010-11-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8004944 Medline TA: Exp Lung Res Country: England |
Other Details:
|
Languages: eng Pagination: 342-51 Citation Subset: IM |
Affiliation:
|
Clinic for Anaesthesiology and Intensive Care Therapy, University Hospital Carl Gustav Carus, Technical University of Dresden, Dresden, Germany. joerg.bleyl@uniklinikum-dresden.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anti-Inflammatory Agents / pharmacology* Blood Pressure / drug effects Cytoprotection Disease Models, Animal Dose-Response Relationship, Drug Fluorocarbons / pharmacology* Inflammation Mediators / metabolism Inhalation / drug effects Leukocytes / drug effects, immunology Lung / blood supply, drug effects*, immunology, pathology, physiopathology Lung Injury / chemically induced, immunology, pathology, physiopathology, prevention & control* N-Formylmethionine Leucyl-Phenylalanine* Organ Size / drug effects Perfusion Pulmonary Artery / drug effects, physiopathology Pulmonary Edema / chemically induced, prevention & control Rabbits Time Factors Volatilization |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Inflammatory Agents; 0/Fluorocarbons; 0/Inflammation Mediators; 355-42-0/perfluorohexane; 59880-97-6/N-Formylmethionine Leucyl-Phenylalanine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Murine mechanical ventilation stimulates alveolar epithelial cell proliferation.
Next Document: N-acetylcysteine protects alveolar epithelial cells from hydrogen peroxide-induced apoptosis through...