| Pretreatment with footshock alters some effects of subsequent organophosphate exposure. | |
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MedLine Citation:
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PMID: 15713337 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pre-exposure to non-chemical stressors may alter a subject's vulnerability to chemical stressors. We found recently that rats given a subtoxic dose of chlorfenvinphos (CVP), an organophosphorus pesticide, develop behavioral hyposensitivity to amphetamine (AMPH). The present experiments were performed in order to find out whether pre-exposure to a non-chemical stressor several days prior to CVP exposure could influence this effect of the pesticide. In experiment 1 adult male Wistar rats were subjected once to either a short, 5 min (SFS) or long, 20 min (LFS) series of unavoidable footshocks (FS). Twenty-four hours or 14 days after the FS, their open field behavior was tested before and after a test dose of AMPH (0.5 mg/kg. i.p). In experiment 2, the rats were subjected to LFS and 14 days later they were injected intraperitoneally with CVP (1.0 mg/kg) or vehicle (corn oil). In both experiments, serum corticosterone (CORT) levels were determined in separate groups of rats in order to assess the magnitude of the stress response induced by the applied stressors. It was found that: (i) the rise in serum CORT concentration after SFS or LFS was similar in magnitude, while that following LFS was more persistent; (ii) exposure to LFS, but not to SFS, resulted in a decreased response to AMPH on day 14 after the experience; (iii) in rats not pretreated with LFS, CVP exposure resulted in a profound increase in serum CORT concentration. In LFS pretreated rats, however, this effect was significantly reduced; (iv) three weeks after the exposure to CVP, the psychomotor response to AMPH was diminished in control rats but was normal in LFS pretreated animals. The results indicate that pretreatment with a non-chemical stressor may protect the rat against at least some of the effects of an organophosphate pesticide. |
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Authors:
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Sławomir Gralewicz; Piotr Lutz; Barbara Kur |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Neurotoxicology Volume: 26 ISSN: 0161-813X ISO Abbreviation: Neurotoxicology Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-02-16 Completed Date: 2005-05-03 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7905589 Medline TA: Neurotoxicology Country: Netherlands |
Other Details:
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Languages: eng Pagination: 159-71 Citation Subset: IM |
Affiliation:
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Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, 8 Teresy St., 90-950 Lodz, Poland. gralslaw@imp.lodz.pl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amphetamine
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pharmacology Animals Chlorfenvinphos / administration & dosage Electroshock / methods* Male Motor Activity / drug effects*, physiology Phosphoric Acid Esters / administration & dosage* Rats Rats, Wistar Stress, Physiological / blood |
| Chemical | |
Reg. No./Substance:
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0/Phosphoric Acid Esters; 300-62-9/Amphetamine; 470-90-6/Chlorfenvinphos |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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