Document Detail

Pretreatment with finasteride decreases perioperative bleeding associated with transurethral resection of the prostate.
MedLine Citation:
PMID:  10792079     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The efficacy of finasteride in the treatment of gross hematuria associated with benign prostatic hyperplasia is well established. We evaluated a regimen of pretreatment with finasteride in decreasing perioperative bleeding associated with transurethral resection of the prostate (TURP). METHODS: A prospective analysis compared 25 patients pretreated with finasteride for 2 to 4 months before TURP with 50 patients without pretreatment. Patients in each group were further separated by the amount of prostate tissue resected. Patients were then followed up for perioperative bleeding, defined as a perioperative blood transfusion requirement or a return visit to the emergency room with gross hematuria or clot retention. RESULTS: None of the patients with less than 30 g of prostate tissue resected experienced perioperative bleeding. In patients with 30 g or more resected, several episodes of bleeding occurred. In the patients pretreated with finasteride, 1 (8.3%) of 12 experienced perioperative bleeding; in the control group, 7 (36.8%) of 19 had an episode of bleeding. CONCLUSIONS: In patients with large prostate glands undergoing TURP, pretreatment with finasteride appears useful in reducing perioperative bleeding.
J A Hagerty; P C Ginsberg; J D Harmon; R C Harkaway
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Urology     Volume:  55     ISSN:  0090-4295     ISO Abbreviation:  Urology     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-05-30     Completed Date:  2000-05-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  684-9     Citation Subset:  IM    
Department of Surgery, Division of Urology, Albert Einstein Medical Center and Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania, USA.
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MeSH Terms
Aged, 80 and over
Blood Loss, Surgical / prevention & control*
Finasteride / therapeutic use*
Middle Aged
Preoperative Care
Prospective Studies
Prostatectomy / adverse effects*
Reg. No./Substance:

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