Document Detail

Pretreatment with fentanyl and propofol attenuates myocardial injury in rabbits with acute hemorrhagic shock.
MedLine Citation:
PMID:  19059609     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Many studies have shown that preconditioning with anesthetics can be used to simulate the myocardial protective effects of ischemic preconditioning. But it is still not certain whether they can protect the myocardium in hemorrhagic shock. This study was designed to examine the myocardial protective effects of propofol and fentanyl in acute hemorrhagic shock. MATERIALS AND METHODS: Thirty-six white rabbits were randomly divided into a control group (group C), propofol preconditioning group (group P), and fentanyl preconditioning group (group F). The animal model of acute hemorrhagic shock was established according to Wigger's method. The same volumes of saline, propofol (5 mg/kg), or fentanyl (25 microg/kg) were administered 15 min before bleeding. Left ventricular function parameters were monitored continuously during 90 min of hemorrhagic shock. Serum cardiac troponin I (cTn-I) was detected by chemiluminescence before bleeding and 60 and 90 min after bleeding. Myocardial samples were taken for morphological studies. RESULTS: Compared with group C, the hemodynamic indexes in group F and group P were higher at each time point of shock (P < 0.05). The cTn-I values in group P and group F were lower than in group C (P < 0.05). Electron microscopic examination of the myocardium indicated that the alterations of myocardial structure and mitochondria were less pronounced in both group F and group P. CONCLUSIONS: Propofol and fentanyl preconditioning can protect the heart against acute ischemia and promote the recovery of hemodynamics during hemorrhagic shock.
Linong Yao; Jianke Kuai; Xiaofeng Liu; Daihua Yu; Yonghui Yang; Lei Tao; Xiaoli Zeng; Wei Chai
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Publication Detail:
Type:  Journal Article     Date:  2008-08-24
Journal Detail:
Title:  The Journal of surgical research     Volume:  155     ISSN:  1095-8673     ISO Abbreviation:  J. Surg. Res.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-22     Completed Date:  2009-07-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  25-31     Citation Subset:  IM    
Department of Anesthesiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
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MeSH Terms
Anesthetics, Intravenous / pharmacology,  therapeutic use*
Fentanyl / pharmacology,  therapeutic use*
Hemodynamics / drug effects
Ischemic Preconditioning, Myocardial
Myocardial Ischemia / blood,  etiology,  pathology,  prevention & control*
Myocardium / ultrastructure
Propofol / pharmacology,  therapeutic use*
Shock, Hemorrhagic / blood,  complications,  drug therapy*
Troponin I / blood
Reg. No./Substance:
0/Anesthetics, Intravenous; 0/Troponin I; 2078-54-8/Propofol; 437-38-7/Fentanyl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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