Document Detail


Pretreatment with estrogen does not affect IVF-ICSI cycle outcome compared with no pretreatment in GnRH antagonist protocol: a prospective randomized trial.
MedLine Citation:
PMID:  22464760     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess effects of estrogen pretreatment in GnRH antagonist protocol.
DESIGN: Prospective, randomized multicenter study.
SETTING: Ten private or university-based centers.
PATIENT(S): A total of 472 patients undergoing IVF/ICSI.
INTERVENTION(S): Randomization by sealed envelopes to receive 17β-estradiol (4 mg/d) or no pretreatment before daily recombinant FSH administration started on the first day of estrogen discontinuation or on cycle day 2 in nonpretreated women.
MAIN OUTCOME MEASURE(S): The primary outcome measure was the number of retrieved oocytes. Secondary efficacy variables included total FSH dose, cycle duration, and outcome.
RESULT(S): The mean numbers of retrieved oocytes (10.9 ± 5.7 vs. 10.2 ± 5.6) and obtained embryos (5.5 ± 3.7 vs. 4.8 ± 3.7) were not significantly different between women allocated to estrogen pretreatment (n = 238) and no pretreatment (n = 234). Total FSH amount (1,557 ± 408 vs. 1,389 ± 347 IU) and stimulation duration (10.8 ± 1.4 vs. 10.0 ± 1.5 days) were slightly but significantly increased in pretreated patients. Positive pregnancy tests, ultrasound pregnancy rate, and delivery rate per cycle were similar (36%, 33%, and 26.6%, respectively, vs. 38.2%, 35.4%, and 30%).
CONCLUSION(S): These data confirm that estrogen pretreatment is associated with requirement of higher FSH doses and longer duration of stimulation without any significant increase in the number of retrieved oocytes. However, estrogen does not affect cycle outcome and therefore might be used in clinical practice for programming IVF retrievals during working days.
CLINICAL TRIALS REGISTRATION NUMBER: NCT01489852.
Authors:
Isabelle Cédrin-Durnerin; Anne Guivarc'h-Levêque; Jean-Noël Hugues;
Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial     Date:  2012-03-28
Journal Detail:
Title:  Fertility and sterility     Volume:  97     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-04     Completed Date:  2012-08-07     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1359-64.e1     Citation Subset:  IM    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Affiliation:
Service de Médecine de la Reproduction, Hôpital Jean Verdier, Assistance Publique-Hôpitaux de Paris, Université Paris XIII, Bondy, France. isabelle.cedrin-durnerin@jvr.ap-hop-paris.fr
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT01489852
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MeSH Terms
Descriptor/Qualifier:
Adult
Drug Therapy, Combination
Estradiol / administration & dosage*
Estrogens / administration & dosage
Estrous Cycle / drug effects
Female
Fertilization in Vitro / methods*
Follicle Stimulating Hormone / administration & dosage*
Gonadotropin-Releasing Hormone / antagonists & inhibitors*
Humans
Oocyte Retrieval / methods
Ovulation Induction / methods*
Pregnancy
Pregnancy Rate
Prospective Studies
Recombinant Proteins / administration & dosage
Sperm Injections, Intracytoplasmic / methods*
Chemical
Reg. No./Substance:
0/Estrogens; 0/Recombinant Proteins; 33515-09-2/Gonadotropin-Releasing Hormone; 50-28-2/Estradiol; 9002-68-0/Follicle Stimulating Hormone
Investigator
Investigator/Affiliation:
Isabelle Parneix / ; Claudine Vasseur / ; Paul Bettina Bständig / ; Florence Lesourd / ; Gérard Marcollin / ; Agnès Colombel /
Comments/Corrections
Comment In:
Fertil Steril. 2012 Jun;97(6):1299-300   [PMID:  22656307 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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