Document Detail


Pretreatment with dexmedetomidine: altered indices of anesthetic depth for halothane in the neuraxis of cats.
MedLine Citation:
PMID:  10072018     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
IMPLICATIONS: The anesthetic adjuvant dexmedetomidine seems to differentially alter central nervous system-mediated indices of anesthetic action. Lower brainstem or spinal determinants of anesthetic depth (movement and hemodynamic responses) are more attenuated than those of higher brain functions, such as the electroencephalogram.
Authors:
W T Schmeling; P Ganjoo; M Staunton; C Drexler; N E Farber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  88     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-03-25     Completed Date:  1999-03-25     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  625-32     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesiology, The Medical College of Wisconsin, Milwaukee 53226, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Agonists / pharmacokinetics,  pharmacology*
Anesthetics, Inhalation / pharmacokinetics,  pharmacology*
Animals
Blood Pressure / drug effects
Brain / drug effects*,  physiology*
Cats
Drug Combinations
Electroencephalography / drug effects
Female
Halothane / pharmacokinetics,  pharmacology*
Heart Rate / drug effects
Imidazoles / pharmacokinetics,  pharmacology*
Male
Medetomidine
Pulmonary Alveoli / metabolism
Grant Support
ID/Acronym/Agency:
R01 GM56398-01/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Anesthetics, Inhalation; 0/Drug Combinations; 0/Imidazoles; 151-67-7/Halothane; 86347-14-0/Medetomidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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