Document Detail


Pretreatment with d-tubocurarine, vecuronium, and pancuronium attenuates succinylcholine-induced increases in plasma norepinephrine concentrations in humans.
MedLine Citation:
PMID:  1670598     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied in patients the effect of d-tubocurarine, which has sympathetic ganglion blocking action, on succinylcholine-induced increases in plasma levels of catecholamines, and compared it with the effects of vecuronium and pancuronium, which have little sympathetic ganglion blocking action. Thirty-two patients were divided into five groups: seven were given 3 mL saline; seven received 1 mg/kg succinylcholine; and six, seven, and five patients were given 0.08 mg/kg d-tubocurarine, 0.01 mg/kg vecuronium, and 0.01 mg/kg pancuronium, respectively, all of which were injected 5 min before 1 mg/kg succinylcholine. Succinylcholine alone significantly increased plasma norepinephrine concentrations, systolic blood pressure, and heart rate from 187 +/- 39 pg/mL (mean +/- SEM), 93 +/- 2 mm Hg, and 77 +/- 4 beats/min to 429 +/- 61 pg/mL, 120 +/- 7 mm Hg, and 102 +/- 6 beats/min, respectively, with onset of fasciculations. Pretreatment with d-tubocurarine, vecuronium, and pancuronium significantly and equally attenuated both the fasciculations and the cardiovascular responses to succinylcholine. These results suggest that the sympathetic ganglion blocking action of neuromuscular relaxants when given before succinylcholine is not an important factor in attenuation of succinylcholine-induced increases in plasma levels of catecholamines.
Authors:
S Oshita; S Denda; Y Fujiwara; H Takeshita; F Kosaka
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  72     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-01-18     Completed Date:  1991-01-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  84-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesiology-Resuscitology, Yamaguchi University Hospital, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure / drug effects
Depression, Chemical
Female
Heart Rate / drug effects
Humans
Male
Norepinephrine / blood*
Pancuronium / pharmacology*
Stimulation, Chemical
Succinylcholine / antagonists & inhibitors*
Tubocurarine / pharmacology*
Vecuronium Bromide / pharmacology*
Chemical
Reg. No./Substance:
0/Pancuronium; 306-40-1/Succinylcholine; 50700-72-6/Vecuronium Bromide; 51-41-2/Norepinephrine; 57-95-4/Tubocurarine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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