| Pretreatment with adenosine and adenosine A1 receptor agonist protects against intestinal ischemia-reperfusion injury in rat. | |
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MedLine Citation:
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PMID: 17278219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To examine the effects of adenosine and A1 receptor activation on reperfusion-induced small intestinal injury. METHODS: Rats were randomized into groups with sham operation, ischemia and reperfusion, and systemic treatments with either adenosine or 2-chloro-N(6)-cyclopentyladenosine, A1 receptor agonist or 8-cyclopentyl-1,3-dipropylxanthine, A1 receptor antagonist, plus adenosine before ischemia. Following reperfusion, contractions of ileum segments in response to KCl, carbachol and substance P were recorded. Tissue myeloperoxidase, malondialdehyde, and reduced glutathione levels were measured. RESULTS: Ischemia significantly decreased both contraction and reduced glutathione level which were ameliorated by adenosine and agonist administration. Treatment also decreased neutrophil infiltration and membrane lipid peroxidation. Beneficial effects of adenosine were abolished by pretreatment with A1 receptor antagonist. CONCLUSION: The data suggest that adenosine and A1 receptor stimulation attenuate ischemic intestinal injury via decreasing oxidative stress, lowering neutrophil infiltration, and increasing reduced glutathione content. |
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Authors:
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V Haktan Ozacmak; Hale Sayan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 13 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-02-05 Completed Date: 2007-03-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 538-47 Citation Subset: IM |
Affiliation:
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Department of Physiology, School of Medicine, Zonguldak Karaelmas University, Kozlu 67600, Zonguldak, Turkey. vhaktan@yahoo.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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administration & dosage*,
analogs & derivatives* Animals Glutathione / analysis Ileum / drug effects, physiology Intestines / blood supply* Male Muscle Contraction / drug effects Peroxidase / metabolism Rats Rats, Wistar Receptor, Adenosine A1 / agonists* Reperfusion Injury / prevention & control* Thiobarbituric Acid Reactive Substances / analysis Xanthines / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Receptor, Adenosine A1; 0/Thiobarbituric Acid Reactive Substances; 0/Xanthines; 102146-07-6/1,3-dipropyl-8-cyclopentylxanthine; 37739-05-2/2-chloro-N(6)cyclopentyladenosine; 58-61-7/Adenosine; 70-18-8/Glutathione; EC 1.11.1.7/Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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