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Pretreatment with Jieduxiezhuo decoction impedes elevations in serum uric acid levels in mice.
MedLine Citation:
PMID:  24660613     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
OBJECTIVE: To investigate whether Jieduxiezhuo decoction (JDXZD) can prevent serum uric acid elevations in mice.
METHODS: Hyperuricemia in mice was induced by intraperitoneally administering uric acid (250 mg/ kg). Concentrations of uric acid in serum were determined using the uric acid enzyme method. Mice were treated with JDXZD for 4 days before uric acid was administered.
RESULTS: After intraperitoneal injection of uric acid, serum uric acid concentrations in mice significantly increased. However, the levels of uric acid in groups pretreated with 16.25 or 4.06 g/kg of JDXZD were significantly lower than those in the model and normal groups.
CONCLUSION: Pretreatment with JDXZD slowed increases in serum uric acid levels in mice intraperitoneally administered uric acid.
Authors:
Yingyi Pan; Zhifeng Chu; Wenjuan Wang; Baican Yang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan / sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine     Volume:  33     ISSN:  0255-2922     ISO Abbreviation:  J Tradit Chin Med     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2014-03-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211546     Medline TA:  J Tradit Chin Med     Country:  China    
Other Details:
Languages:  eng     Pagination:  794-7     Citation Subset:  IM    
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