Document Detail

Pretreatment with FK506 improves survival rate and gas exchange in canine model of acute lung injury.
MedLine Citation:
PMID:  11208629     Owner:  NLM     Status:  MEDLINE    
The novel effects of FK506 on shock induced by lipopolysaccharide and phorbol myristate acetate (LPS/PMA) were studied using beagles. Five groups were studied: endotoxin shock control group (both 0.5 mg/kg of LPS and 30 microg/kg of PMA, n = 6); methylprednisolone-treated endotoxin shock group (n = 5); FK506-treated endotoxin shock groups in which intravenous infusions of FK506 at 2.5 microg/kg/h (low dose, n = 5), 8 microg/kg/h (medium dose, n = 5), and 25 microg/kg/h (high dose, n = 5) were administered. In the control group, the survival rate was 33%. Also, arterial hypoxemia, systemic hypotension, and marked increases in pulmonary vascular resistance (PVR) and wet-to-dry weight ratio (W/D) were observed. FK506 treatment at both medium and high doses significantly attenuated these LPS/PMA-induced physiological changes, and the survival rates were 80 and 100%, respectively. On the other hand, in the methylprednisolone group, no obvious effects were observed. The present study suggests that FK506 could have prophylactic potential against acute lung injury in endotoxin shock.
T Koshika; A Ishizaka; I Nagatomi; Y Sudo; N Hasegawa; T Goto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  163     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-03-06     Completed Date:  2001-05-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  79-84     Citation Subset:  AIM; IM    
Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Company, Osaka, and Department of Medicine, School of Medicine, Keio University, Tokyo, Japan.
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MeSH Terms
Immunosuppressive Agents / therapeutic use*
Organ Size
Pulmonary Gas Exchange / drug effects*
Respiratory Distress Syndrome, Adult / etiology,  mortality*,  pathology,  physiopathology,  prevention & control*
Shock, Septic / complications,  mortality*,  physiopathology,  prevention & control*
Survival Rate
Tacrolimus / therapeutic use*
Reg. No./Substance:
0/Immunosuppressive Agents; 109581-93-3/Tacrolimus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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