| Pretreatment of sperm with low hypo-osmotic swelling tests with chymotrypsin prior to intrauterine insemination (IUI) and avoidance of unprotectected intercourse results in pregnancy rates comparable to IUI for other male factor problems. | |
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MedLine Citation:
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PMID: 21077521 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To carry out a retrospectively performed matched controlled study to determine the efficacy of pretreatment of sperm having low hypo-osmotic swelling (HOS) test scores with chymotrypsin galactose prior to intrauterine insemination (IUI) compared to IUI for other types of male factor problems. The women with male partners with low HOS scores were advised not to have unprotected intercourse. METHODS: All cycles having IUI with chymotrypsin treated sperm for low HOS scores were matched with the very next woman having IUI for sperm with other male factor problems but with normal HOS scores. RESULTS: There was a significantly higher clinical pregnancy rate with chymotrypsin treated sperm (32.3% per IUI) vs. 21.9% for other male factor cases. The live birth rate per IUI cycle was not significantly different (21.2% vs. 15.4%). CONCLUSIONS: These results now show that pretreatment of sperm with low HOS scores allows very good pregnancy rates following IUI as long as the couple is cautioned about unprotected intercourse. These data support the concept that sperm with low HOS test scores impair fertility by transferring a toxic factor from the sperm to the zona pellucida to the embryo membrane which impairs the embryos from implanting. |
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Authors:
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G Citrino; J H Check; A Diantonio; A Bollendorf; D Katsoff |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental obstetrics & gynecology Volume: 37 ISSN: 0390-6663 ISO Abbreviation: Clin Exp Obstet Gynecol Publication Date: 2010 |
Date Detail:
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Created Date: 2010-11-16 Completed Date: 2010-12-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7802110 Medline TA: Clin Exp Obstet Gynecol Country: Italy |
Other Details:
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Languages: eng Pagination: 187-9 Citation Subset: IM |
Affiliation:
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The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chymotrypsin
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pharmacology* Coitus Contraception Female Galactose / pharmacology Humans Insemination, Artificial* Live Birth Male Matched-Pair Analysis Osmolar Concentration Pregnancy Pregnancy Rate* Retrospective Studies Semen Analysis Spermatozoa / drug effects*, physiology* |
| Chemical | |
Reg. No./Substance:
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26566-61-0/Galactose; EC 3.4.21.1/Chymotrypsin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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