| Pretreatment of sperm with human follicular fluid for borderline male infertility. | |
| | |
MedLine Citation:
|
PMID: 2707464 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To test the usefulness of human follicular fluid (FF) in treating male infertility, we incubated washed sperm specimens from 31 couples undergoing intrauterine insemination (IUI), for male and/or unexplained infertility, with either FF or Ham's F-10 medium (Gibco, Grand Island, NY), in alternating cycles in a randomized manner. Semen specimens from 28 men were incubated with either medium or FF. Incubations with FF have increased sperm penetration assay (SPA) scores from 24.8 +/- 17.3 to 34.3 +/- 13.6 (P less than 0.01). Incubation with heat-inactivized FF also has increased SPA scores, although to a lesser extent than noninactivized FF. Seventeen pregnancies occurred in the 31 couples treated by IUI (54.8%), 16 of them in FF-treated cycles (51.6%) and one in "control" IUI cycles (3.2%, P less than 0.01). All pregnancies occurred within four treatment cycles. Thus, IUI after sperm wash and preincubation with FF may be suggested for four to six cycles to couples with male factor and/or unexplained infertility who are reluctant to resort to artificial insemination by donor or adoption, before attempting the more costly and complex in vitro fertilization-embryo transfer procedure. |
| | |
Authors:
|
Z Blumenfeld; F Nahhas |
Related Documents
:
|
3609154 - Benign testicular hyperplasia in mongolian gerbils (meriones unguiculatus). 2566274 - Sulphasalazine-induced reversible male infertility. 2820454 - Therapeutic value of hysterosalpingography with lipiodol ultra fluid. 6439974 - Surgical management of endometriosis with the carbon dioxide laser. 19587334 - Noninvasive monitoring of reproductive activity based on fecal progestagen profiles and... 18407634 - 2-fluoro-atp as a versatile tool for 19f nmr-based activity screening. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Fertility and sterility Volume: 51 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 1989 May |
Date Detail:
|
Created Date: 1989-06-07 Completed Date: 1989-06-07 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 863-8 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Rambam Medical Center, Haifa, Israel. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Body Fluids
/
analysis,
physiology* Female Humans Infertility, Male / physiopathology, therapy* Insemination, Artificial Male Ovarian Follicle / analysis* Pregnancy Pregnancy Outcome Sperm-Ovum Interactions Spermatozoa / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: General and anomalous sperm disappearance characteristics found in a large vasectomy series.
Next Document: Spermicidal effect of antagonists of platelet-activating factor.