| Pretreatment and early intratreatment prediction of clinicopathologic response of head and neck cancer to chemoradiotherapy using 1H-MRS. | |
| | |
MedLine Citation:
|
PMID: 20578027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To determine if choline (cho) identified by proton magnetic resonance spectroscopy ((1)H-MRS) performed pretreatment and early in the course of treatment predicts clinicopathologic response of head and neck squamous cell carcinoma (HNSCC). MATERIALS AND METHODS: In all, 60 patients with HNSCC scheduled to undergo concurrent chemoradiotherapy or radiotherapy alone were recruited. (1)H-MRS was performed pretreatment and early intratreatment (2 weeks after start of treatment). Cho:creatine and cho:water ratios at each timepoint and change in the ratios between the two timepoints were correlated with locoregional failure, distant metastases, overall survival, and cancer-related death. Statistical analysis was performed using logistic regression and chi-square and a P-value of < 0.05 was considered statistically significant. RESULTS: Cho was identified in 47/49 successful pretreatment spectra and 42 of these 47 underwent successful (1)H-MRS early intratreatment, of which 21 showed persistent cho. Locoregional failure occurred in 15, distant metastases in 6, and death in 15 patients; the follow-up period in survivors ranged from 13-64 months (mean, 39 months). No statistically significant correlation was found between (1)H-MRS parameters and clinical endpoints. CONCLUSION: The pretreatment cho and change in cho early during a course of treatment did not predict clinical outcome. |
| | |
Authors:
|
Ann D King; David K W Yeung; Kwok-hung Yu; Frankie K F Mo; Kunwar S Bhatia; Gary M K Tse; Alexander C Vlantis; Jeffrey K T Wong; Chen-wen Hu; Anil T Ahuja |
Related Documents
:
|
16117877 - Proton magnetic resonance spectroscopy of normal human brain and glioma: a quantitative... 12068347 - Fourth ventricle computed tomography indexes: standardisation and characteristics in ne... 12353277 - Maturation of the human fetal brain as observed by 1h mr spectroscopy. 3366647 - Local cerebral glucose utilization in the ammon's horn and dentate gyrus of the rat brain. 3357037 - Traumatic epidural hematoma of the cervical spine: diagnosis with magnetic resonance im... 16606047 - Ferroelectricity in spiral magnets. |
Publication Detail:
|
Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of magnetic resonance imaging : JMRI Volume: 32 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-06-29 Completed Date: 2010-10-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
|
Languages: eng Pagination: 199-203 Citation Subset: IM |
Copyright Information:
|
(c) 2010 Wiley-Liss, Inc. |
Affiliation:
|
Department of Diagnostic Radiology & Organ Imaging, Faculty of Medicine, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR China. king2015@cuhk.edu.hk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Carcinoma, Squamous Cell / drug therapy*, metabolism, radiotherapy* Choline / metabolism Female Follow-Up Studies Head and Neck Neoplasms / drug therapy*, metabolism, radiotherapy* Humans Magnetic Resonance Spectroscopy / methods* Male Middle Aged Predictive Value of Tests Prospective Studies Survival Analysis Treatment Outcome Tumor Markers, Biological / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Tumor Markers, Biological; 62-49-7/Choline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Reproducibility of black blood dynamic contrast-enhanced magnetic resonance imaging in aortic plaque...
Next Document: Iterative image reconstruction for PROPELLER-MRI using the nonuniform fast fourier transform.