Document Detail


Pretreatment dietary patterns, weight status, and head and neck squamous cell carcinoma prognosis.
MedLine Citation:
PMID:  23269814     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Few studies have evaluated the association of diet and weight status with head and neck cancer outcomes.
OBJECTIVE: The purpose of this study was to determine whether pretreatment dietary patterns and weight status are associated with head and neck cancer prognosis.
DESIGN: This was a longitudinal study of 542 patients with newly diagnosed head and neck cancer who completed food-frequency questionnaires and health surveys before treatment. Clinical data were abstracted from medical records and the Social Security Death Index. Dietary patterns were identified by using principal component analysis. Cox proportional hazard models were used to examine the association of derived dietary patterns (fit by quintiles of exposure) and weight status with time to recurrence and survival, with control for covariates.
RESULTS: During the study period, there were 229 deaths and 184 recurrences. Two dietary patterns were identified: a whole-foods pattern (characterized by high intakes of vegetables, fruit, fish, poultry, and whole grains) and a Western pattern (characterized by high intakes of red and processed meats, refined grains, potatoes, and French fries). In multivariable analyses, significantly fewer deaths were observed in subjects most adherent to the whole-foods pattern (HR: 0.56; 95% CI: 0.34, 0.92; P-trend = 0.01). Subjects classified as overweight or obese had significantly fewer deaths (HR: 0.65; 95% CI: 0.49, 0.85; P = 0.001) and recurrences (HR: 0.70; 95% CI: 0.52, 0.95; P = 0.02) than did normal-weight or underweight subjects.
CONCLUSION: Consumption of a diet rich in vegetables, fruit, fish, poultry, and whole grains and being overweight before diagnosis with head and neck cancer are associated with a better prognosis.
Authors:
Anna E Arthur; Karen E Peterson; Laura S Rozek; Jeremy M G Taylor; Emily Light; Douglas B Chepeha; James R Hébert; Jeffrey E Terrell; Gregory T Wolf; Sonia A Duffy;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-12-26
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  97     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-21     Completed Date:  2013-03-19     Revised Date:  2014-04-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  360-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Body Mass Index
Carcinoma, Squamous Cell / complications,  diagnosis*,  prevention & control
Diet* / adverse effects
Female
Functional Food
Head and Neck Neoplasms / complications,  diagnosis*,  prevention & control
Humans
Longitudinal Studies
Male
Michigan
Middle Aged
Neoplasm Recurrence, Local / prevention & control
Obesity / complications*
Overweight / complications*
Prognosis
Prospective Studies
Survival Analysis
Young Adult
Grant Support
ID/Acronym/Agency:
CA097248/CA/NCI NIH HHS; K05 CA136975/CA/NCI NIH HHS
Comments/Corrections

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