Document Detail


Pretreatment With Xenon Protected Immature Rabbit Heart From Ischaemia/Reperfusion Injury by Opening of the mitoK(ATP) Channel.
MedLine Citation:
PMID:  23261327     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: The noble gas anaesthetic, xenon has previously been shown to protect the adult myocardium from ischaemia/reperfusion (I/R) injury, however its effect on immature myocardium is unclear. The aim of this study was to investigate the effect of xenon on the isolated immature heart. METHODS: Isolated, immature (2-3weeks old) New Zealand rabbit hearts were perfused with Krebs-Henseleit buffer via Langendorff-mode. After 20min of baseline equilibration, hearts were pretreated with 75% xenon, 75% xenon+100μM diazoxide, or 75% xenon+100μM 5-hydroxydecanoate, and then subjected to 1h of global ischaemia and 3h of reperfusion. RESULTS: Pretreatment with 75% xenon significantly improved cardiac function (P<0.01 vs. the I/R group, respectively), limited myocardial infarct size (20.83±2.16%, P<0.01 vs. 35.82±2.14% of the I/R group), reduced cardiac enzyme release (CK-MB, 1.00±0.19IU/L, P<0.01 vs. 0.44±0.14IU/L of the I/R group; LDH, 6.15±1.06IU/L P<0.01 vs. 3.49±0.37IU/L of the I/R group) and decreased apoptosis (6.17±0.56%, P<0.01 vs. 11.31±0.93% of the I/R group). In addition, the mitochondrial structure changes caused by I/R injury were largely prevented by 75% xenon pretreatment (1.37±0.16, P<0.01 vs. 2.32±0.13 of the I/R group). The mitochondrial adenosine triphosphate-sensitive potassium (mitoK(ATP)) channel opener diazoxide did not influence the effect of xenon, but the specific mitoK(ATP) channel blocker 5-hydroxydecanoate completely abolished this effect. CONCLUSIONS: Our study demonstrated that pretreatment with 75% xenon protected immature heart from I/R injury, and this protection was probably mediated by preservation of myocardial mitochondria and opening of mitoK(ATP) channel.
Authors:
Qian Li; Chunwei Lian; Ronghua Zhou; Tao Li; Xujin Xiang; Bin Liu
Related Documents :
1081017 - Significance of new q waves after aortocoronary bypass surgery. correlation with change...
25090937 - Left atrial dysfunction detected by speckle tracking in patients with systemic sclerosis.
7410997 - Increase in r-wave amplitude during transient epicardial injury (prinzmetal type).
6481277 - Fluctuations in t-wave morphology and susceptibility to ventricular fibrillation.
2353657 - Measurement of intracardiac dimensions and structures in normal young adult subjects by...
9197427 - Serial prognostic capabilities of electrocardiographic indices of infarcted and hiberna...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-20
Journal Detail:
Title:  Heart, lung & circulation     Volume:  -     ISSN:  1444-2892     ISO Abbreviation:  Heart Lung Circ     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100963739     Medline TA:  Heart Lung Circ     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.
Affiliation:
Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of IKK? on oxidised low-density lipoprotein-induced injury in vascular endothelial cells.
Next Document:  Early Experience of Transaortic TAVI-The Future of Surgical TAVI?