| Pretransplant risk score for new-onset diabetes after kidney transplantation. | |
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MedLine Citation:
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PMID: 21949218 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE New-onset diabetes after kidney transplantation (NODAT) has adverse clinical and economic implications. A risk score for NODAT could help identify research subjects for intervention studies. RESEARCH DESIGN AND METHODS We conducted a single-center retrospective cohort study using pretransplant clinical and laboratory measurements to construct a risk score for NODAT. NODAT was defined by hemoglobin A(1c) (HbA(1c)) ≥6.5%, fasting serum glucose ≥126 mg/dL, or prescribed therapy for diabetes within 1 year posttransplant. Three multivariate logistic regression models were constructed: 1) standard model, with both continuous and discrete variables; 2) dichotomous model, with continuous variables dichotomized at clinically relevant cut points; and 3) summary score defined as the sum of the points accrued using the terms from the dichotomous model. RESULTS A total of 316 subjects had seven pretransplant variables with P < 0.10 in univariate logistic regression analyses (age, planned corticosteroid therapy posttransplant, prescription for gout medicine, BMI, fasting glucose and triglycerides, and family history of type 2 diabetes) that were selected for multivariate models. Areas under receiver operating curves for all three models were similar (0.72, 0.71, and 0.70). A simple risk score calculated as the sum of points from the seven variables performed as well as the other two models in identifying risk of NODAT. CONCLUSIONS A risk score computed from seven simple pretransplant variables can identify risk of NODAT. |
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Authors:
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Harini A Chakkera; E Jennifer Weil; Christine M Swanson; Amylou C Dueck; Raymond L Heilman; Kunam S Reddy; Khaled Hamawi; Hasan Khamash; Adyr A Moss; David C Mulligan; Nitin Katariya; William C Knowler |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Diabetes care Volume: 34 ISSN: 1935-5548 ISO Abbreviation: Diabetes Care Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: United States |
Other Details:
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Languages: eng Pagination: 2141-5 Citation Subset: IM |
Affiliation:
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Corresponding author: Harini A. Chakkera, chakkera.harini@mayo.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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