Document Detail

Pretransplant conditioning with busulfan and cyclophosphamide in acute leukemia patients: neurological and electroencephalographic prospective study.
MedLine Citation:
PMID:  1606085     Owner:  NLM     Status:  MEDLINE    
A neurological and electroencephalographic (EEG) prospective study was performed in 34 leukemic patients receiving busulfan (BU) plus cyclophosphamide (CY) before bone marrow autologous transplant. During BU treatment and briefly thereafter, all patients were given anticonvulsant prophylaxis with phenobarbital. Neurological evaluations were performed daily and EEGs, recorded one week before and soon after the end of the BU regimen, were re-evaluated two months later. Basal EEGs were normal in 23 of the 34 patients, focal abnormalities were detected in 9 cases, and generalized epileptic discharges were present in one (one subject was not studied). EEGs performed at the end of BU administration showed generalized spike/polyspike-and-wave discharges in 21 of the 34 patients, with associated myoclonic epilepsy in 10 subjects appearing on the 3rd or 4th day of treatment. Focal abnormalities were present in 6 patients and constant EEG normality in 7. It is known that myoclonic epilepsy can be induced by drugs. Oral administration of high-dose BU is followed by a high-dose cerebrospinal fluid concentration of the drug. Therefore, myoclonic epilepsy and/or paroxysmal epileptiform EEG discharges may be observed in leukemic patients undergoing high-dose BU therapy.
G Meloni; U Raucci; R M Pinto; A Spalice; M Vignetti; P Iannetti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of oncology : official journal of the European Society for Medical Oncology / ESMO     Volume:  3     ISSN:  0923-7534     ISO Abbreviation:  Ann. Oncol.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-07-17     Completed Date:  1992-07-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9007735     Medline TA:  Ann Oncol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  145-8     Citation Subset:  IM    
Department of Biopathology, University La Sapienza, Rome, Italy.
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MeSH Terms
Acute Disease
Antineoplastic Combined Chemotherapy Protocols / adverse effects*,  therapeutic use
Barbiturates / therapeutic use
Bone Marrow Transplantation / methods*
Busulfan / administration & dosage
Child, Preschool
Clonazepam / therapeutic use
Combined Modality Therapy
Cyclophosphamide / administration & dosage
Electroencephalography / drug effects*
Leukemia, Lymphoid / drug therapy*,  surgery
Leukemia, Myeloid / drug therapy*,  surgery
Middle Aged
Myoclonus / chemically induced
Nervous System Diseases / chemically induced*,  epidemiology
Prospective Studies
Reg. No./Substance:
0/Barbiturates; 1622-61-3/Clonazepam; 50-18-0/Cyclophosphamide; 55-98-1/Busulfan; 67-52-7/barbituric acid

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