| Pretherapeutic identification of high-risk acute myeloid leukemia (AML) patients from immunophenotypic, cytogenetic, and clinical parameters. | |
| | |
MedLine Citation:
|
PMID: 12717685 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The goal of this study concerned the pretherapeutic identification of high-risk acute myeloid leukemia (AML) patients by data pattern analysis from flow cytometric immunophenotype, cytogenetic, and clinical data. METHODS: Sixty-seven parameters of AML patients at diagnosis were classified for predictive information by algorithmic data sieving using iteratively self optimizing triple matrix data pattern analysis (http://www.biochem.mpg.de/valet/classif1.html). RESULTS: Pretherapeutic predictive values for nonsurvival within five years and two years were 100.0% and 83.2%, respectively, compared to 13.9% and 47.4% for the prediction of survival at five years and two years, respectively. At diagnosis, five-year nonsurvivors showed increased patient age and higher concentration of cells in the analyzed specimen, as well as increased levels of % CD2, CD4, CD13, CD36, and CD45 positive AML blasts. Two-year nonsurvivors were characterized by a data pattern of increased patient age and levels of % CD4, CD7, CD11b, CD24, CD45, TH126, and HLA-DR positive AML blasts and decreased levels of % CD1, CD65, CD95, and TC25 positive AML blasts. Cytogenetic abnormalities were not selected for the optimized discriminatory data patterns. CONCLUSIONS: The comparatively accurate pretherapeutic identification of high-risk AML patients may prove useful for the development of individualized therapy protocols in stratified clinical patients groups. |
| | |
Authors:
|
G Valet; R Repp; H Link; A Ehninger; M Gramatzki M; |
Related Documents
:
|
16493615 - Role of cyp2d6, cyp1a1, cyp2e1, gstt1, and gstm1 genes in the susceptibility to acute l... 19781775 - Immunophenotypic features of acute myeloid leukemia with inv(3)(q21q26.2)/t(3;3)(q21;q2... 8371595 - Monitoring of adult b-cell lineage acute lymphoblastic leukemia: validation of a simple... 10218045 - Oral hairy leukoplakia in a patient with acute lymphocytic leukemia. 17950085 - Short-term outcomes of parathyroidectomy in patients with or without 25-hydroxy vitamin... 8574715 - Antibiotic prophylaxis for ercp: a randomized clinical trial comparing ciprofloxacin an... |
Publication Detail:
|
Type: Journal Article; Multicenter Study |
Journal Detail:
|
Title: Cytometry. Part B, Clinical cytometry Volume: 53 ISSN: 1552-4949 ISO Abbreviation: Cytometry B Clin Cytom Publication Date: 2003 May |
Date Detail:
|
Created Date: 2003-04-28 Completed Date: 2004-02-20 Revised Date: 2009-12-11 |
Medline Journal Info:
|
Nlm Unique ID: 101235690 Medline TA: Cytometry B Clin Cytom Country: United States |
Other Details:
|
Languages: eng Pagination: 4-10 Citation Subset: IM |
Copyright Information:
|
Copyright 2003 Wiley-Liss, Inc. |
Affiliation:
|
Max-Planck-Institut für Biochemie, Martinsried, Germany. valet@biochem.mpg.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Computational Biology Flow Cytometry* Humans Immunophenotyping Leukemia, Myeloid / mortality*, pathology* Predictive Value of Tests Prognosis Risk Factors Survival Analysis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cytomics in predictive medicine.
Next Document: Immunophenotyping is an independent factor for risk stratification in AML.