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Preterm twin and triplet pregnancies are at increased risk for the development of cystic periventricular leukomalacia.
MedLine Citation:
PMID:  22795624     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: An increased risk of cerebral palsy in multiples has been reported. AIMS: To determine the risk for the development of periventricular leukomalacia (PVL) of twin and triplet pregnancy. STUDY DESIGN: Retrospective single-centre study at a tertiary care university hospital. SUBJECTS: Infants ≤35 weeks gestational age born between 1988 and 2008. OUTCOME MEASURES: Risk of twin and triplet compared to singleton pregnancy regarding development of PVL in one offspring. RESULTS: Of 6195 infants 117 singletons and 39 multiples were diagnosed as having cystic PVL. Perinatal data did not differ as did not ultrasonographic findings and neurologic outcome. The relative risk (RR) of a twin pregnancy resulting in at least one infant with PVL when born prior to 36 weeks was 2.181 (CI 95% 1.474-3.228, p < .0001), and 6.793 (CI 95% 2.470-13.108, p < .0001) of a triplet pregnancy. In-vitro fertilisation was present in 3% of affected twins compared to 100% in triplets (p < .001). CONCLUSION: We found an increased risk for PVL in preterm twin and triplet pregnancies.
Authors:
B Resch; E Resch; T Freidl; U Maurer; J Haas; W Müller
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-11
Journal Detail:
Title:  European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society     Volume:  -     ISSN:  1532-2130     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9715169     Medline TA:  Eur J Paediatr Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Research Unit for Neonatal Infectious Diseases and Epidemiology, Medical University of Graz, Austria; Division of Neonatology, Department of Paediatrics, Medical University of Graz, Austria.
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