Document Detail

Preterm and term labour in multiple pregnancies.
MedLine Citation:
PMID:  20643592     Owner:  NLM     Status:  MEDLINE    
The association between multiple pregnancy and preterm labour is well-established, with >50% of multiple births delivering before 37 weeks. However, there remains limited understanding of the factors predisposing to early delivery of twins. Physiological stimuli to the onset of parturition, including stretch, placental corticotrophin-releasing hormone and lung maturity factors, may be stronger in multiple pregnancies due to the increased fetal and placental mass. Pathological processes including infection and cervical insufficiency also have a role. Treatments that prevent preterm birth in singleton pregnancies, such as progesterone and cervical cerclage appear to be ineffective in multiple pregnancies. This article reviews aspects of preterm birth in twins and higher order multiples including epidemiology, prediction and prevention of preterm labour and potential mechanisms controlling onset of parturition. Evidence relating to the management of labour in preterm and term multiples is also discussed.
Sarah Stock; Jane Norman
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Seminars in fetal & neonatal medicine     Volume:  15     ISSN:  1878-0946     ISO Abbreviation:  Semin Fetal Neonatal Med     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-10-18     Completed Date:  2011-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101240003     Medline TA:  Semin Fetal Neonatal Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  336-41     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
University of Edinburgh Division of Reproductive and Developmental Sciences, Room S7129, Simpson Centre for Reproductive Health, Royal Infirmary of Edinburgh, Little France, Edinburgh EH16 4SA, UK.
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MeSH Terms
Cerclage, Cervical / adverse effects
Delivery, Obstetric / methods
Obstetric Labor, Premature / epidemiology,  physiopathology,  prevention & control*
Pregnancy, Multiple* / physiology
Prenatal Care / methods*
Prenatal Diagnosis
Progesterone / administration & dosage,  therapeutic use
Progestins / administration & dosage,  therapeutic use
Risk Factors
Term Birth*
Twins / physiology
Grant Support
//Chief Scientist Office
Reg. No./Substance:
0/Progestins; 57-83-0/Progesterone

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