| Preterm prelabour rupture of the membranes before 28 weeks: better than feared outcome of expectant management in Africa. | |
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MedLine Citation:
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PMID: 16229934 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To document the prognosis after conservative management of patients with membrane rupture at gestations less than 28 weeks. STUDY DESIGN: Prospective observational study of 78 women with confirmed membrane rupture at less than 28 weeks gestation, managed conservatively. Antibiotics were given from the time of membrane rupture till delivery. Patients were delivered if clinical infection supervened, there was fetal compromise, spontaneous labour ensued or if the pregnancy continued to 34 completed weeks gestation. RESULTS: The mean gestational age at membrane rupture was 23.3+/-3.17 weeks (16.5-27.8) and the median 24 weeks. Mean latency period was 24.1+/-29.1 days (1.5-154) with a median of 12.5 days. Eight women (10%) delivered between 24 and 48 h, 25 (32%) within 7 days and 55 (70%) within 1 month. Of note is that 23 patients (30%) had latency periods of greater than 1 month. The mean gestational age at delivery was 26.7+/-3.92 weeks. Overall of the 78 women there were 81 fetuses delivered, of which 35 (43%) survived. Survival was related to latency period, birth weight and gestational age at delivery. Sixteen women (20%) developed chorioamnionitis. There was no increase in the incidence of clinical infection with increasing latency period. Compression limb abnormalities occurred in 17% of neonates and lung hypoplasia in 18%. CONCLUSION: Conservative management of patients with very preterm prelabour membrane rupture offers a survival rate of at least 40% with no serious complications in a study of 78 women. |
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Authors:
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Chantal J M Stewart; Shaun K Tregoning; G Moller; H Wainwright |
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Publication Detail:
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Type: Journal Article Date: 2005-10-17 |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 126 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-05-29 Completed Date: 2006-08-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 186-92 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, University of Cape Town Medical School, Anzio Road, Observatory 7925, Cape Town, South Africa. cstewart@global.co.za |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Birth Weight Chorioamnionitis Female Fetal Membranes, Premature Rupture / epidemiology*, etiology, pathology, therapy* Gestational Age Humans Infant, Newborn Outcome Assessment (Health Care)* Perinatal Care* Pregnancy Pregnancy Outcome Pregnancy Trimester, Second Prognosis Prospective Studies South Africa / epidemiology |
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