Document Detail

Preterm outcomes research: a critical component of neonatal intensive care.
MedLine Citation:
PMID:  12454898     Owner:  NLM     Status:  MEDLINE    
While early preterm outcome studies described the lives of preterm survivors to justify the efforts required to save them, subsequent studies demonstrated their increased incidence of cerebral palsy, mental retardation, sensory impairments, minor neuromotor dysfunction, language delays, visual-perceptual disorders, learning disability and behavior problems compared to fullterm controls. Because infants born at the lower limit of viability require the most resources and have the highest incidence of neurodevelopmental disability, there is concern that resources have gone primarily to neonatal intensive care and are not available for meeting the followup, health, educational and emotional needs of these fragile infants and their families. Despite many methodological concerns, preterm outcome studies have provided insight into risk factors for and causes of CNS injury in preterm infants. Nevertheless, it remains difficult to predict neurodevelopmental outcome for individual preterm infants. Perinatal and neonatal risk factors are inadequate proxies for neurodevelopmental disability. Recent randomized controlled trials with one to five year neurodevelopmental followup have provided valuable information about perinatal and neonatal treatments. Recognizing adverse longterm neurodevelopmental effects of pharmacological doses of postnatal steroids is a sobering reminder of the need for longterm neurodevelopmental followup in all neonatal randomized controlled trials. Ongoing longterm preterm neurodevelopmental studies, analysis of changes in outcomes over time and among centers, and evaluation of the longterm safety, efficacy and effectiveness of many perinatal and neonatal management strategies and proposed neuroprotective agents are all necessary for further medical and technological advances in neonatal intensive care.
Marilee C Allen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Mental retardation and developmental disabilities research reviews     Volume:  8     ISSN:  1080-4013     ISO Abbreviation:  Ment Retard Dev Disabil Res Rev     Publication Date:  2002  
Date Detail:
Created Date:  2002-11-27     Completed Date:  2003-04-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9517974     Medline TA:  Ment Retard Dev Disabil Res Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  221-33     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Wiley-Liss, Inc.
The Johns Hopkins Hospital, Baltimore, Maryland 21287-3200, USA.
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MeSH Terms
Infant, Newborn
Infant, Newborn, Diseases / etiology,  mortality,  rehabilitation*
Infant, Premature
Infant, Very Low Birth Weight
Intensive Care, Neonatal*
Survival Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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