| Preterm outcomes research: a critical component of neonatal intensive care. | |
| | |
MedLine Citation:
|
PMID: 12454898 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
While early preterm outcome studies described the lives of preterm survivors to justify the efforts required to save them, subsequent studies demonstrated their increased incidence of cerebral palsy, mental retardation, sensory impairments, minor neuromotor dysfunction, language delays, visual-perceptual disorders, learning disability and behavior problems compared to fullterm controls. Because infants born at the lower limit of viability require the most resources and have the highest incidence of neurodevelopmental disability, there is concern that resources have gone primarily to neonatal intensive care and are not available for meeting the followup, health, educational and emotional needs of these fragile infants and their families. Despite many methodological concerns, preterm outcome studies have provided insight into risk factors for and causes of CNS injury in preterm infants. Nevertheless, it remains difficult to predict neurodevelopmental outcome for individual preterm infants. Perinatal and neonatal risk factors are inadequate proxies for neurodevelopmental disability. Recent randomized controlled trials with one to five year neurodevelopmental followup have provided valuable information about perinatal and neonatal treatments. Recognizing adverse longterm neurodevelopmental effects of pharmacological doses of postnatal steroids is a sobering reminder of the need for longterm neurodevelopmental followup in all neonatal randomized controlled trials. Ongoing longterm preterm neurodevelopmental studies, analysis of changes in outcomes over time and among centers, and evaluation of the longterm safety, efficacy and effectiveness of many perinatal and neonatal management strategies and proposed neuroprotective agents are all necessary for further medical and technological advances in neonatal intensive care. |
| | |
Authors:
|
Marilee C Allen |
Related Documents
:
|
17666618 - Prediction and prevention of recurrent spontaneous preterm birth. 22712688 - Raising obstetricians' awareness of spinal muscular atrophy: towards early detection an... 20978088 - Consanguinity: a risk factor for preterm birth at less than 33 weeks' gestation. 1415408 - Birth weight threshold for postponing preterm birth. 23468888 - Altered glutamatergic metabolism associated with punctate white matter lesions in prete... 22643168 - Should babies be watching television and dvds? |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Mental retardation and developmental disabilities research reviews Volume: 8 ISSN: 1080-4013 ISO Abbreviation: Ment Retard Dev Disabil Res Rev Publication Date: 2002 |
Date Detail:
|
Created Date: 2002-11-27 Completed Date: 2003-04-04 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9517974 Medline TA: Ment Retard Dev Disabil Res Rev Country: United States |
Other Details:
|
Languages: eng Pagination: 221-33 Citation Subset: IM |
Copyright Information:
|
Copyright 2002 Wiley-Liss, Inc. |
Affiliation:
|
The Johns Hopkins Hospital, Baltimore, Maryland 21287-3200, USA. mcallen@jhmi.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Hospitalization Humans Infant, Newborn Infant, Newborn, Diseases / etiology, mortality, rehabilitation* Infant, Premature Infant, Very Low Birth Weight Intensive Care, Neonatal* Survival Rate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prematurity at birth: trends, racial disparities, and epidemiology.
Next Document: Cognitive and neuropsychological outcomes: more than IQ scores.