Document Detail

Preterm neonatal cardiovascular instability: does understanding the fetus help evaluate the newborn?
MedLine Citation:
PMID:  22780577     Owner:  NLM     Status:  Publisher    
Preterm newborns, particularly very low birth weight newborns, frequently experience intermittent hypotension and/or hypoperfusion. Organ perfusion is largely distinct from systemic hypotension, suggesting that changes in underlying vascular tone are the major determinants of perfusion. Preterm fetuses have a remarkable anaerobic tolerance and ability to survive major insults with no or limited injury, balanced by relative immaturity of key autonomic responses. Exposure to hypoxia-ischaemia and infection trigger complex changes in vascular tone that evolve over many days, and there is evidence that these are centrally controlled, and in part linked with underlying organ metabolism. Hypoperfusion frequently occurs after hypoxia-ischaemia without organ injury occurring. Hypoxia-ischaemia, infection and many clinical interventions such as steroid therapy and ventilation can interact to increase or decrease the risk of brain injury. © 2012 The Authors Clinical and Experimental Pharmacology and Physiology © 2012 Blackwell Publishing Asia Pty Ltd.
Laura Bennet; Lindsea C Booth; Paul P Drury; Josine S L Quaedackers; Alistair J Gunn
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-10
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  -     ISSN:  1440-1681     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors Clinical and Experimental Pharmacology and Physiology © 2012 Blackwell Publishing Asia Pty Ltd.
Fetal Physiology and Neuroscience Group, Department of Physiology, Faculty of Medical and Health, The University of Auckland, New Zealand.
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