| Preterm labor: placental pathology and clinical correlation. | |
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MedLine Citation:
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PMID: 10432144 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the relevance of ischemia in the incidence of preterm labor. A second objective was to document perinatal outcomes for patients with preterm labor classified according to its clinical, functional, and pathologic characteristics (infectious, ischemic, mixed, or idiopathic). METHODS: Perinatal outcomes were evaluated for 145 consecutive patients with preterm labor, subdivided into etiologic categories according to clinical, functional (Doppler), and morphologic (placental pathology) characteristics. A group of 44 normal pregnancies delivered at term served as controls. RESULTS: Of the preterm labor group, 28.3% were classified as ischemic, compared with 4.5% of the control group (odds ratio and 95% confidence interval = 8.28 [1.8, 51.8]; P < .05). Compared with the control group, the preterm labor patients who delivered preterm had higher rates of ischemia (31.4% compared with 4.5%; P < .05) and infection (16.1% compared with 2.3%; P < .05). Among the preterm labor group, patients classified in the infectious or ischemic subgroups had a higher rate of preterm delivery (95.0% and 90.2% compared with 73.2%; P < .05), admission to the neonatal intensive care unit (75.0% and 61.0% compared with 40.0%; P < .05), and newborn weight under 1500 g (35.0% and 19.5% compared with 3.7%; P < .05) than the idiopathic subgroup. CONCLUSION: Preterm labor resulting from infection or ischemia is associated with a higher perinatal complication rate than idiopathic preterm labor. |
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Authors:
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A M Germain; J Carvajal; M Sanchez; G J Valenzuela; H Tsunekawa; B Chuaqui |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 94 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 1999 Aug |
Date Detail:
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Created Date: 1999-08-30 Completed Date: 1999-08-30 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 284-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Medical Research Center, Pontificia Universidad Católica de Chile School of Medicine, Santiago. agermain@med.puc.cl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Humans Ischemia / complications* Obstetric Labor, Premature / epidemiology, etiology* Placenta / blood supply*, pathology* Pregnancy |
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