Document Detail

Preterm labor and accidental hemorrhage after disopyramide therapy in pregnancy. A case report.
MedLine Citation:
PMID:  10442335     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Treatment of arrhythmias during pregnancy is complicated by concerns about the safety of antiarrhythmic therapy. This is the first case report of preterm labor and abruptio placentae following the administration of disopyramide during pregnancy. CASE: A 26-year-old woman, gravida 2, para 1, was diagnosed as having Wolff-Parkinson-White syndrome during the third trimester of pregnancy. Recurrent episodes of supra-ventricular tachycardia were refractory to medical therapy and required repeated direct current cardioversion. Administration of disopyramide led to the initiation of painful uterine contractions and accidental hemorrhage. CONCLUSION: Caution must be exercised during the use of disopyramide during pregnancy, and intensive monitoring should be instituted to avoid adverse maternal and fetal effects.
M Abbi; A Kriplani; B Singh
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  44     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-10-21     Completed Date:  1999-10-21     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  653-5     Citation Subset:  IM    
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi.
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MeSH Terms
Abruptio Placentae / chemically induced*,  complications
Anti-Arrhythmia Agents / adverse effects*
Disopyramide / adverse effects*
Obstetric Labor, Premature / chemically induced*
Pregnancy Complications, Cardiovascular / drug therapy*
Pregnancy Trimester, Third
Tachycardia, Supraventricular / drug therapy,  etiology
Uterine Hemorrhage / etiology
Wolff-Parkinson-White Syndrome / complications,  drug therapy*
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 3737-09-5/Disopyramide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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