| Preterm infant formula supplementation with alpha linolenic acid and docosahexaenoic acid. | |
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MedLine Citation:
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PMID: 12792656 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To investigate if supplementation of preterm infant formula with a high docosahexaenoic acid/eicosapentaenoic acid (DHA/EPA) ratio together with alpha-linolenic acid (ALA) was able to maintain plasma and red blood cell DHA levels similar to that obtained with breast milk feeding without altering n-6 fatty acid status. DESIGN AND SUBJECTS: Preterm infants of mothers who elected not to breast feed (n=13) were assigned to ALA- and DHA-enriched formula (DHA group: DHA/EPA=5/l). Infants fed breast milk (n=25) constituted a reference group (BM group). Anthropometric and fatty acid parameters (plasma phospholipids, cholesterol esters, triglycerides and red blood cell phosphatidylethanolamine, PL, CE, TG, RBC-PE, respectively) were obtained after 2 days (D2) and 15 days (D15) of enteral feeding and at the 37th week (W37) of post-conception age and 1 month later (W37+30) in the DHA group. Mean DHA intake ranged between 16.5+/-1.6 and 17.9+/-2.9 mg/kg/day between D2 and W37+30. RESULTS: At W37, infant weights, heights, and head circumferences were similar in DHA and BM groups. PL DHA was maintained in the DHA group at the same level as in the BM group and the same for DHA in PE at W37. In RBC-PE and at W37, AA status was the same in both groups. In PL, AA levels remained very stable throughout the study; however, in the DHA group AA levels in PL remained in the range observed with standard formulas. CONCLUSION: The combined 18:3 n-3 and DHA supplementation of infant formula with DHA/EPA ratio 5/l is compatible with growth and n-3 fatty acid metabolism similar to that of preterm infants fed human milk. |
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Authors:
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A Rodriguez; D Raederstorff; P Sarda; C Lauret; F Mendy; B Descomps |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: European journal of clinical nutrition Volume: 57 ISSN: 0954-3007 ISO Abbreviation: Eur J Clin Nutr Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-06-06 Completed Date: 2003-09-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8804070 Medline TA: Eur J Clin Nutr Country: England |
Other Details:
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Languages: eng Pagination: 727-34 Citation Subset: IM |
Affiliation:
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Laboratoire de Biochimie A, EA Nutrition Humaine et Athérogenèse, UMI, Institut de Biologie, Boulevard Henri IV, 34060 Montpellier, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Dietary Supplements Docosahexaenoic Acids / administration & dosage, pharmacology* Fatty Acids, Omega-3 / metabolism* Growth / drug effects* Humans Infant Food* Infant, Newborn Infant, Premature Milk, Human / metabolism alpha-Linolenic Acid / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Omega-3; 25167-62-8/Docosahexaenoic Acids; 463-40-1/alpha-Linolenic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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