Document Detail

Preterm delivery in normoalbuminuric, diabetic women without preeclampsia: the role of metabolic control.
MedLine Citation:
PMID:  16139943     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to examine the importance of glycemic regulation on the risk of preterm delivery in women with normoalbuminuria and no preeclampsia later in pregnancy. STUDY DESIGN AND METHODS: A prospective study of 71 women with type 1 diabetes mellitus where complete data were collected on HbA1c, insulin dose, and albumin excretion rate from week 12 and every second week hereafter. Fundus photography was performed and diurnal blood pressure measured three times during pregnancy. RESULTS: The preterm rate was 23% and women delivering preterm showed higher HbA1c throughout pregnancy. At regression analysis HbA1c was the strongest predictor for preterm delivery from week 6 to 32, also when including insulin dose, BMI, age, duration of diabetes, and diurnal blood pressure. The risk of delivering preterm was more than 40% when HbA1c was above 7.7% in week 8. Diurnal blood pressure was not found associated with preterm delivery. CONCLUSION: The quality of glycemic regulation in the early and mid-pregnancy is a major, independent risk factor for preterm delivery in normoalbuminuric diabetic women without preeclampsia.
Finn F Lauszus; Jens Fuglsang; Allan Flyvbjerg; Joachim G Klebe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-09-01
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  124     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-27     Completed Date:  2007-08-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  144-9     Citation Subset:  IM    
Department of Obstetrics/Gynecology, Aarhus University Hospital, Denmark.
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MeSH Terms
Analysis of Variance
Blood Pressure
Body Mass Index
Diabetes Complications / metabolism*,  physiopathology,  prevention & control
Diabetes Mellitus, Type 1 / drug therapy,  metabolism*,  physiopathology
Gestational Age
Hemoglobin A, Glycosylated / analysis*
Hypoglycemic Agents / administration & dosage
Infant, Newborn
Infant, Premature
Insulin / administration & dosage
Obstetric Labor, Premature / etiology*,  prevention & control
Pregnancy Outcome
Pregnancy in Diabetics / drug therapy,  metabolism*,  physiopathology
Prospective Studies
Risk Factors
Reg. No./Substance:
0/Hemoglobin A, Glycosylated; 0/Hypoglycemic Agents; 11061-68-0/Insulin

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