Document Detail


Preterm delivery after indomethacin. A risk factor for neonatal complications?
MedLine Citation:
PMID:  8979204     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine if tocolytic therapy with indomethacin is associated with an increased risk of neonatal complications in infants born prior to 32 weeks' gestation. STUDY DESIGN: We performed a retrospective matched cohort study of infants born between 24 and 31(6)/7 weeks' gestation. The 62 cases (indomethacin treatment) and the 62 controls were matched by week of gestation, prenatal betamethasone exposure and multifetal gestation. RESULTS: The mean gestational age of the two groups was 28.5 +/- SD weeks. The median total dose of indomethacin was 425 mg, the median treatment duration was three days, and the median interval from the last dose of indomethacin until delivery was one day. There was no significant difference between the groups in the incidence of necrotizing enterocolitis, intraventricular hemorrhage, patent ductus arteriosis, sepsis or neonatal death. CONCLUSION: The use of indomethacin for tocolysis was not associated with an increased risk of neonatal complications in infants born between 24 and 31(6)/7 weeks' gestation.
Authors:
M O Gardner; J Owen; S Skelly; J C Hauth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  41     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-03-17     Completed Date:  1997-03-17     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  903-6     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, University of New Mexico, Albuquerque 87131-5286, USA.
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MeSH Terms
Descriptor/Qualifier:
Cohort Studies
Ductus Arteriosus, Patent / chemically induced,  epidemiology
Enterocolitis, Pseudomembranous / chemically induced,  epidemiology
Female
Hemorrhage / chemically induced,  epidemiology
Humans
Incidence
Indomethacin / adverse effects*,  pharmacology
Infant, Newborn
Infant, Newborn, Diseases / chemically induced*,  epidemiology*
Obstetric Labor, Premature / prevention & control*
Pregnancy
Respiratory Distress Syndrome, Newborn / chemically induced,  epidemiology
Retrospective Studies
Risk Factors
Tocolytic Agents / adverse effects*,  pharmacology
Chemical
Reg. No./Substance:
0/Tocolytic Agents; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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