Document Detail


Preterm cerebellar growth impairment after postnatal exposure to glucocorticoids.
MedLine Citation:
PMID:  22013125     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
As survival rates of preterm newborns improve as a result of better medical management, these children increasingly show impaired cognition. These adverse cognitive outcomes are associated with decreases in the volume of the cerebellum. Because animals exhibit reduced preterm cerebellar growth after perinatal exposure to glucocorticoids, we sought to determine whether glucocorticoid exposure and other modifiable factors increased the risk for these adverse outcomes in human neonates. We studied 172 preterm neonatal infants from two medical centers, the University of British Columbia and the University of California, San Francisco, by performing serial magnetic resonance imaging examinations near birth and again near term-equivalent age. After we adjusted for associated clinical factors, antenatal betamethasone was not associated with changes in cerebellar volume. Postnatal exposure to clinically routine doses of hydrocortisone or dexamethasone was associated with impaired cerebellar, but not cerebral, growth. Alterations in treatment after preterm birth, particularly glucocorticoid exposure, may help to decrease risk for adverse neurological outcome after preterm birth.
Authors:
Emily W Y Tam; Vann Chau; Donna M Ferriero; A James Barkovich; Kenneth J Poskitt; Colin Studholme; Eric D-Y Fok; Ruth E Grunau; David V Glidden; Steven P Miller
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Science translational medicine     Volume:  3     ISSN:  1946-6242     ISO Abbreviation:  Sci Transl Med     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-20     Completed Date:  2012-05-29     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  101505086     Medline TA:  Sci Transl Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  105ra105     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cerebellum / drug effects*,  growth & development*,  pathology
Female
Glucocorticoids / adverse effects*
Humans
Infant, Newborn
Infant, Premature
Magnetic Resonance Imaging
Male
Grant Support
ID/Acronym/Agency:
151135//Canadian Institutes of Health Research; R01 NS046432/NS/NINDS NIH HHS; R01 NS055064/NS/NINDS NIH HHS; R01 NS055064/NS/NINDS NIH HHS; R01 NS055064-04/NS/NINDS NIH HHS; R01 NS061957/NS/NINDS NIH HHS; R01 NS061957/NS/NINDS NIH HHS; R01 NS061957-02/NS/NINDS NIH HHS; R01 NS346432/NS/NINDS NIH HHS; UL1 RR024131/RR/NCRR NIH HHS; UL1 RR024131/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Glucocorticoids
Comments/Corrections
Comment In:
Sci Transl Med. 2011 Oct 19;3(105):105ps40   [PMID:  22013122 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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