| Preterm birth and risk of medically treated hypothyroidism in young adulthood. | |
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MedLine Citation:
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PMID: 21521303 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Previous studies suggest that low birth weight is associated with thyroid autoimmunity and hypothyroidism in later life, but the potential effect of preterm birth, independent of foetal growth, is unknown. Our objective was to determine whether preterm birth is independently associated with medically treated hypothyroidism in young adulthood. DESIGN/PARTICIPANTS: National cohort study of 629,806 individuals born in Sweden from 1973 through 1979, including 27,935 born preterm (<37 weeks). MEASUREMENTS: Thyroid hormone prescription during 2005-2009 (ages 25·5-37·0 years), obtained from all outpatient and inpatient pharmacies throughout Sweden. RESULTS: Preterm birth was associated with increased relative odds of thyroid hormone prescription in young adulthood, after adjusting for foetal growth and other potential confounders. This association appeared stronger among twins than singletons (P = 0·04 for the interaction). Twins had increased relative odds across the full range of preterm gestational ages, whereas singletons had increased relative odds only if born very preterm (23-31 weeks). Among twins and singletons, respectively, adjusted odds ratios for individuals born preterm (<37 weeks) were 1·54 (95% CI, 1·11-2·14) and 1·08 (95% CI, 0·98-1·19), and for individuals born very preterm (23-31 weeks) were 2·62 (95% CI, 1·30-5·27) and 1·59 (95% CI, 1·18-2·14), relative to full-term births. CONCLUSIONS: This national cohort study suggests that preterm birth is associated with an increased risk of medically treated hypothyroidism in young adulthood. This association was independent of foetal growth and appeared stronger among twins than singletons. Additional studies are needed to confirm these new findings in other populations and to elucidate the mechanisms. |
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Authors:
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Casey Crump; Marilyn A Winkleby; Jan Sundquist; Kristina Sundquist |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical endocrinology Volume: 75 ISSN: 1365-2265 ISO Abbreviation: Clin. Endocrinol. (Oxf) Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-06 Completed Date: 2011-12-27 Revised Date: 2012-09-25 |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: England |
Other Details:
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Languages: eng Pagination: 255-60 Citation Subset: IM |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Department of Medicine, Stanford University, Palo Alto, CA, USA. kccrump@stanford.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cohort Studies Fetal Development Humans Hypothyroidism / drug therapy, etiology* Odds Ratio Premature Birth / physiopathology* Risk Sweden / epidemiology Twins Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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1R01HD052848-01/HD/NICHD NIH HHS; R01 HD052848-01A1/HD/NICHD NIH HHS |
| Comments/Corrections | |
Comment In:
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Nat Rev Endocrinol. 2011 Jun;7(6):312
[PMID:
21502979
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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