| Preterm birth risk assessment. | |
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MedLine Citation:
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PMID: 11561909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Preterm birth is a leading cause of peripheral morbidity and mortality. The national rate of prematurity approaches 11%. In spite of widespread tocolytic use, the preterm birth rate has actually increased over the past 30 years in the United States. Preterm birth appears to have a multifactorial etiology. Leading theories include infectious, inflammatory or ischemic insult to the uteroplacental barrier, activation of the fetal hypothalamic-pituitary pathway, decreased cervical competence, and pathologic uterine distention. Multiple biochemical and biophysical markers have been studied for their potential to correctly identify women at risk of preterm delivery. Of these, fetal fibronectin and endovaginal ultrasound examination of the cervix have proven effective in predicting which symptomatic women are actually at low risk of preterm birth. Salivary estriol is being studied as a marker for preterm labor and delivery and it too will likely be found to be a reliable risk identifier in a high risk population. However, home uterine activity monitoring has not been shown to decrease the frequency of preterm birth or its neonatal complications. |
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Authors:
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J G Mauldin; R B Newman |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in perinatology Volume: 25 ISSN: 0146-0005 ISO Abbreviation: Semin. Perinatol. Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-09-19 Completed Date: 2002-02-08 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7801132 Medline TA: Semin Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 215-22 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston 29425, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cervix Uteri
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pathology Estriol / analysis Female Fibronectins* Glycoproteins / analysis Home Care Services Humans Infant Mortality Infant, Newborn Obstetric Labor, Premature* Pregnancy Risk Assessment Saliva / chemistry Uterine Monitoring |
| Chemical | |
Reg. No./Substance:
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0/FFN protein, human; 0/Fibronectins; 0/Glycoproteins; 50-27-1/Estriol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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