Document Detail


Preterm birth risk assessment.
MedLine Citation:
PMID:  11561909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Preterm birth is a leading cause of peripheral morbidity and mortality. The national rate of prematurity approaches 11%. In spite of widespread tocolytic use, the preterm birth rate has actually increased over the past 30 years in the United States. Preterm birth appears to have a multifactorial etiology. Leading theories include infectious, inflammatory or ischemic insult to the uteroplacental barrier, activation of the fetal hypothalamic-pituitary pathway, decreased cervical competence, and pathologic uterine distention. Multiple biochemical and biophysical markers have been studied for their potential to correctly identify women at risk of preterm delivery. Of these, fetal fibronectin and endovaginal ultrasound examination of the cervix have proven effective in predicting which symptomatic women are actually at low risk of preterm birth. Salivary estriol is being studied as a marker for preterm labor and delivery and it too will likely be found to be a reliable risk identifier in a high risk population. However, home uterine activity monitoring has not been shown to decrease the frequency of preterm birth or its neonatal complications.
Authors:
J G Mauldin; R B Newman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in perinatology     Volume:  25     ISSN:  0146-0005     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-09-19     Completed Date:  2002-02-08     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  215-22     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston 29425, USA.
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MeSH Terms
Descriptor/Qualifier:
Cervix Uteri / pathology
Estriol / analysis
Female
Fibronectins*
Glycoproteins / analysis
Home Care Services
Humans
Infant Mortality
Infant, Newborn
Obstetric Labor, Premature*
Pregnancy
Risk Assessment
Saliva / chemistry
Uterine Monitoring
Chemical
Reg. No./Substance:
0/FFN protein, human; 0/Fibronectins; 0/Glycoproteins; 50-27-1/Estriol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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