Document Detail

Preterm birth reduction after clotrimazole treatment during pregnancy.
MedLine Citation:
PMID:  15358456     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We have previously found an association between the combination of topical and vaginal clotrimazole treatment during pregnancy and a decreased prevalence of preterm births in the population-based data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities. Thus the objective of this secondary analysis in the expanded data set was to evaluate potential confounders and to examine the possible interaction of clotrimazole with other drugs. STUDY DESIGN: Medically recorded birth weight/gestational age, in addition the prevalence of preterm birth and low birthweight infants of newborn infants without birth defects born to mothers with or without clotrimazole treatment during pregnancy were compared in the expanded control data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-1996. RESULTS: The 17-year data set included 38,151 newborn infants and 8.1% were born to mothers who received clotrimazole treatment during pregnancy. There was an increase in mean gestational age among the exposed relative to the unexposed, resulting in a significant (34-64%) reduction in the prevalence of preterm births. This finding could not be explained by confounders and/or interaction with other drugs. CONCLUSION: The protective effect of clotrimazole for preterm birth was confirmed. We conclude that the protective effect of topical clotrimazole during pregnancy may be attributable to the beneficial effect of clotrimazole in the restoration of the abnormal colonization of the female genital organs and its known antibacterial and/or antiprotozoal effect.
Andrew E Czeizel; Bernward Fladung; Peter Vargha
Related Documents :
9809826 - Ciprofloxacin in preterm neonates: case report and review of the literature.
17621496 - Characteristics of amplitude-integrated electroencephalogram in premature infants.
7949796 - Free-radical-induced lipid peroxidation during the early neonatal period.
8116706 - A prospective, randomized, placebo-controlled trial of penicillin in preterm premature ...
23450546 - Nasal versus oral route for placing feeding tubes in preterm or low birth weight infants.
25042036 - Noninvasive molecular fingerprinting of host-microbiome interaction in neonates.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  116     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-10     Completed Date:  2005-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  157-63     Citation Subset:  IM    
Foundation for the Community Control of Hereditary Diseases, Törökvészlejto 32, 1026 Budapest, Hungary.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Intravaginal
Anti-Infective Agents / administration & dosage,  pharmacology*
Anti-Infective Agents, Local / pharmacology
Case-Control Studies
Clotrimazole / administration & dosage,  pharmacology*
Confounding Factors (Epidemiology)
Drug Interactions
Gestational Age
Hungary / epidemiology
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature
Metronidazole / administration & dosage,  pharmacology*
Premature Birth / epidemiology*,  etiology
Retrospective Studies
Treatment Outcome
Reg. No./Substance:
0/Anti-Infective Agents; 0/Anti-Infective Agents, Local; 23593-75-1/Clotrimazole; 443-48-1/Metronidazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Relationship between a toll-like receptor-4 gene polymorphism, bacterial vaginosis-related flora and...
Next Document:  Effectiveness of detection of intrauterine growth retardation by abdominal palpation as screening te...