| Preterm birth and inflammation-The role of genetic polymorphisms. | |
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MedLine Citation:
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PMID: 18783866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Spontaneous preterm labour and preterm births are still the leading cause of perinatal morbidity and mortality in the developed world. Previous efforts to prevent preterm birth have been hampered by a poor understanding of the underlying pathophysiology, inadequate diagnostic tools and generally ineffective therapies. Clinical, epidemiological and experimental studies indicate that genito-urinary tract infections play a critical role in the pathogenesis of preterm birth. Moreover, intrauterine infection increases perinatal mortality and morbidity, such as cerebral palsy and chronic lung disease, significantly. It has recently been suggested that gene-environment interactions play a significant role in determining the risk of preterm birth. Polymorphisms of certain critical genes may be responsible for a harmful inflammatory response in those who possess them. Accordingly, polymorphisms that increase the magnitude or the duration of the inflammatory response were associated with an increased risk of preterm birth. In contrast polymorphisms that decrease the inflammatory response were associated with a lower risk of preterm birth. This article will review the current understanding of pathogenetic pathways in the aetiology of preterm birth. |
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Authors:
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Daniela Holst; Yves Garnier |
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Publication Detail:
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Type: Journal Article; Review Date: 2008-09-09 |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 141 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-11-05 Completed Date: 2009-03-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 3-9 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, University Hospital of Cologne, Köln, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chorioamnionitis
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immunology Cytokines / genetics Female Fetal Membranes, Premature Rupture / genetics*, immunology, microbiology Genetic Predisposition to Disease / genetics* Humans Inflammation / genetics* Matrix Metalloproteinases / genetics Odds Ratio Polymorphism, Single Nucleotide / genetics Pregnancy Premature Birth / genetics*, immunology, microbiology Vaginosis, Bacterial / immunology |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; EC 3.4.24.-/Matrix Metalloproteinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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